S
Steffen Hartmann
Researcher at Novartis
Publications - 6
Citations - 339
Steffen Hartmann is an academic researcher from Novartis. The author has contributed to research in topics: Muscle hypertrophy & Particle size. The author has an hindex of 4, co-authored 5 publications receiving 301 citations.
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Journal ArticleDOI
An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy
Estelle Lach-Trifilieff,Giulia Minetti,Kelly-Ann Sheppard,Chikwendu Ibebunjo,Jerome N. Feige,Steffen Hartmann,Sophie Brachat,Helene Rivet,Claudia Koelbing,Frederic Morvan,Shinji Hatakeyama,David J. Glass +11 more
TL;DR: A novel, human anti-ActRII antibody is developed to prevent binding of ligands to the receptors and thus inhibit downstream signaling in the myostatin/activin type II receptor pathway, highlighting the compelling therapeutic potential of BYM338 for the treatment of skeletal muscle atrophy and weakness in multiple settings.
Journal ArticleDOI
A semi-automated large-scale process for the production of recombinant tagged proteins in the Baculovirus expression system.
Jean-Marc Schlaeppi,Mario Henke,Marion Mahnke,Steffen Hartmann,Rita Schmitz,Yann Pouliquen,Brendan Kerins,Eric Weber,Frank Kolbinger,Hans P. Kocher +9 more
TL;DR: This work has developed an integrated large-scale process for continuous and partially automated protein production in the Baculovirus system and has been validated with 41 His-tagged proteins with molecular weights ranging from 20 to 160 kDa.
Journal ArticleDOI
Rapid protein expression analysis with an interferometric biosensor for monitoring protein production.
TL;DR: The applicability of a label-free sensor system based on a Young interferometer is presented as an alternative for the monitoring of recombinant protein production and exhibited a low limit of detection, low drift and reliable operation is compared with a commercial surface plasmon resonance sensor and a competitive ELISA.
Journal ArticleDOI
Stability liabilities of biotherapeutic proteins: Early assessment as mitigation strategy.
Susana A.L. Lobo,Paulina Bączyk,Brigitte Wyss,Jasmin C. Widmer,Lídia P. Jesus,Joana Gomes,Ana P. Batista,Steffen Hartmann,Paul Wassmann +8 more
TL;DR: Conformational and colloidal stability profiles of three non-immunoglobulin domain based proteins and of two monoclonal antibodies were assessed in dependence of solution pH, ionic strength and varying buffering agents, indicating presence of molecule specific liabilities.