[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

BACKGROUND: The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a standard uncoated stent in patients with angina pectoris. METHODS: We performed a randomized, double-blind trial to compare the two types of stents for revascularization of single, primary lesions in native coronary arteries. The trial included 238 patients at 19 medical centers. The primary end point was in-stent late luminal loss (the difference between the minimal luminal diameter immediately after the procedure and the diameter at six months). Secondary end points included the percentage of in-stent stenosis of the luminal diameter and the rate of restenosis (luminal narrowing of 50 percent or more). We also analyzed a composite clinical end point consisting of death, myocardial infarction, and percutaneous or surgical revascularization at 1, 6, and 12 months. RESULTS: At six months, the degree of neointimal proliferation, manifested as the mean (+/-SD) late luminal loss, was significantly lower in the sirolimus-stent group (-0.01+/-0.33 mm) than in the standard-stent group (0.80+/-0.53 mm, P<0.001). None of the patients in the sirolimus-stent group, as compared with 26.6 percent of those in the standard-stent group, had restenosis of 50 percent or more of the luminal diameter (P<0.001). There were no episodes of stent thrombosis. During a follow-up period of up to one year, the overall rate of major cardiac events was 5.8 percent in the sirolimus-stent group and 28.8 percent in the standard-stent group (P<0.001). The difference was due entirely to a higher rate of revascularization of the target vessel in the standard-stent group. CONCLUSIONS: As compared with a standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis, and associated clinical events.

/pdf/a-randomized-comparison-of-a-sirolimus-eluting-stent-with-a-3h78nze073.pdf

A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization

Alice K. Jacobs, MD, FACC, FAHA, Chair 

Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect 

Nancy Albert, PhD, CCNS, CCRN, FAHA

Mark A. Creager, MD, FACC, FAHA

Steven M. Ettinger, MD, FACC

Robert A. Guyton, MD, FACC

Jonathan L. Halperin, MD, FACC, FAHA

Judith S. Hochman, MD, FACC, FAHA

2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions

http://www.columbiamedicine.org/education/r/Cardiology/ACS/Plavix/PCI-CURE.pdf

Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study.

A 73-year-old woman with a history of high blood pressure and hypercholesterolemia developed medically uncontrolled hypertension (200/100 mm Hg). Serum creatinine level was 145 μmol/L, and creatinine clearance was 34 mL/min. Renal ultrasound demonstrated a small right kidney (80 mm long) compared with the left one (92 mm long). Left ventricular hypertrophy was present on the ECG and was confirmed by echocardiography. On isotope radiography with 99mTc-mercaptoacetyltriglycine after oral intake of 25 mg captopril, the right kidney was small, with delayed excretion and impaired function (36%). Renal arteriography showed subocclusive ostial stenosis of the right renal artery.

The lesion was related to a calcified plaque extending from the aortic wall into the renal artery ostium (angiogram I in Figure 1⇓, arrow). After an unsuccessful angioplasty attempt in the interventional radiology department (failure to cross the stenosis), the patient was investigated in the cardiac catheterization laboratory. The lesion was crossed with a hydrophilic guidewire and predilated. A short (9-mm) stent was then implanted by use of a 4.5-mm balloon inflated up to 18 atm for postdilatation (angiogram II).

The immediate result of the intervention was assessed by both biplane …

Simultaneous Morphological and Functional Assessment of a Renal Artery Stent Intervention With Intravascular Ultrasound

Percutaneous therapy of coronary bifurcated lesions is associated with greater risk of acute complications and late restenosis. Numerous innovative techniques using various stent types have been proposed. We report the first clinical use of a truly bifurcated stent (Bard XT Carina). The implantation procedure, favorable medium-term angiographic and 1-year clinical follow-up of the first human use in a 43-year-old female are illustrated with angiography and intravascular ultrasound. As a single prosthesis that effectively covers the bifurcation, this stent presents appealing alternative for the treatment of coronary bifurcation lesions when compared to methods that involve multiple-stent implantation. Cathet. Cardiovasc. Intervent. 47:361-369, 1999.

Stenting with a true bifurcated stent: acute and mid-term follow-up results

Intravascular ultrasound (IVUS) is a catheter-based modality which is used to produce high-resolution, cross-sectional images of the interior of blood vessels. By capturing 2-D IVUS images continually while translating the catheter, a volumetric image of a vessel may be digitally reconstructed. To improve the quality of these volumes, electrocardiogram (ECG)-based frame gating is often applied to alleviate motion artifacts caused by the beating heart. However, there are several issues surrounding the use of ECG signals which make their use for this purpose potentially suboptimal. We introduce a method which gates pullback sequences by examining the imaging data alone, without requiring synchronous ECG, and guarantees that frames will be collected at those points in time when the heart is maximally motionless (i.e., regardless of the fraction of cardiac phase associated with those points). We compare the results of our method and of ECG on pullbacks captured in vivo in swine.

Image-Based Frame Gating of IVUS Pullbacks: A Surrogate for ECG

Background: Reduced total arterial compliance (TAC) may be a marker of preclinical vascular disease. Irreversible risk factors such as age and body habitus are determinants of TAC, the importance of which may have been hidden by reports in selected subgroups, such as the elderly and those with diabetes mellitus or hypertension. We sought the comparative influence of reversible and irreversible risk factors on TAC in a large primary prevention group. Materials and Methods: We studied 720 consecutive patients with and without cardiovascular risk factors but with no overt cardiovascular disease. TAC was calculated by the pulse-pressure method from simultaneous applanation tonometry and left ventricular outflow tract Doppler. Central pressure was derived using a transfer function from the radial tonometric waveform and calibrated using mean and diastolic brachial cuff pressure. Results: There were 192 patients with no cardiovascular risk factors, 180 patients with one cardiovascular risk factor, 173 patients with two cardiovascular risk factors, and 175 patients with three or more risk factors. Although age, gender, height, weight, hypertension, diabetes mellitus, hyperlipidemia, and number of risk factors were all significantly associated with TAC, age accounted for approximately 13% of the variance, and the only other independent predictors were height and weight. TAC was not significantly different in age-matched subgroups with single risk factors. Conclusion: TAC is associated with multiple risk factors, but age is a major determinant. The influence of age and other correlates may dwarf the contribution of individual risk factors and therefore their alteration with therapy.

Influence of Cardiovascular Risk Factors on Total Arterial Compliance

A67-year-old man with a history of hypertension and hypercholesterolemia was scheduled for elective direct stent implantation for a severe proximal left descending artery stenosis. Using the femoral approach, a 7-French Judkins left guiding catheter was placed in the left coronary ostium. To keep the activated clotting time …

Stephane Carlier

Papers

Simultaneous Morphological and Functional Assessment of a Renal Artery Stent Intervention With Intravascular Ultrasound

Stenting with a true bifurcated stent: acute and mid-term follow-up results

Image-Based Frame Gating of IVUS Pullbacks: A Surrogate for ECG

Influence of Cardiovascular Risk Factors on Total Arterial Compliance

Distal embolization : A threat to the coronary artery ?