S
Stephanie Worton
Researcher at University of Manchester
Publications - 17
Citations - 868
Stephanie Worton is an academic researcher from University of Manchester. The author has contributed to research in topics: Placenta & Metabolome. The author has an hindex of 8, co-authored 17 publications receiving 761 citations. Previous affiliations of Stephanie Worton include Manchester Academic Health Science Centre & Central Manchester University Hospitals NHS Foundation Trust.
Papers
More filters
Journal ArticleDOI
Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review.
Esther F. Davis,Merzaka Lazdam,Adam J. Lewandowski,Stephanie Worton,Brenda Kelly,Yvonne Kenworthy,Satish Adwani,Andrew R. Wilkinson,Kenny McCormick,Ian L. Sargent,Christopher W.G. Redman,Paul Leeson +11 more
TL;DR: Young offspring of pregnancies complicated by preeclampsia already have increased blood pressure and BMI, a finding that may need to be considered in future primary prevention strategies for cardiovascular disease.
Journal ArticleDOI
Antenatal Glucocorticoid Exposure and Long-Term Alterations in Aortic Function and Glucose Metabolism
Brenda Kelly,Adam J. Lewandowski,Stephanie Worton,Esther F. Davis,Merzaka Lazdam,Jane M Francis,Stefan Neubauer,Alan Lucas,Atul Singhal,Paul Leeson +9 more
TL;DR: Antenatal glucocorticoid exposure in preterm infants is associated with increased aortic arch stiffness and altered glucose metabolism in early adulthood, which is equivalent to that of term adults a decade older.
Journal ArticleDOI
Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia.
Warwick B. Dunn,Martin Brown,Stephanie Worton,I.P. Crocker,David Broadhurst,Richard P. Horgan,Richard P. Horgan,Louise C. Kenny,Philip N. Baker,Douglas B. Kell,Alexander E. P. Heazell +10 more
TL;DR: Differences in the factors released from villous trophoblast from uncomplicated pregnancies and those with PE are investigated, suggesting that hypoxia may have a role in the placental pathogenesis of PE.
Journal ArticleDOI
The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy
Warwick B. Dunn,Marie Brown,Stephanie Worton,Kyle Davies,Rebecca Jones,Douglas B. Kell,Alexander E. P. Heazell +6 more
TL;DR: These proof-of-principle studies demonstrate the sensitivity of placental tissue metabolomics to define changes related to alterations in environment and perfusion and related to diseases of pregnancy including preeclampsia.
Journal ArticleDOI
Analysis of the Metabolic Footprint and Tissue Metabolome of Placental Villous Explants Cultured at Different Oxygen Tensions Reveals Novel Redox Biomarkers
Alexander E. P. Heazell,Martin Brown,Warwick B. Dunn,Stephanie Worton,Ian P. Crocker,Philip N. Baker,Douglas B. Kell +6 more
TL;DR: It is concluded that metabolomic strategies offer a novel approach to investigate placental function when conducted under carefully controlled conditions, with appropriate statistical analysis, metabolic differences can be identified in placental explants in response to altered O2 tension.