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Stephen Brimijoin
Researcher at Mayo Clinic
Publications - 202
Citations - 7707
Stephen Brimijoin is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Acetylcholinesterase & Butyrylcholinesterase. The author has an hindex of 47, co-authored 202 publications receiving 7402 citations. Previous affiliations of Stephen Brimijoin include University of Minnesota & University of Nebraska Medical Center.
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Journal ArticleDOI
Antipeptide antibodies confirm the topology of the human norepinephrine transporter
TL;DR: In indirect immunofluorescence studies, the originally proposed topology of hNET was confirmed, with polyclonal antibodies raised against peptides corresponding to hydrophilic sequences of the human norepinephrine transporter confirmed.
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Cholinesterases in neural development: new findings and toxicologic implications.
TL;DR: Developing animals are more sensitive than adults to acute cholinergic toxicity from anticholinesterases, including organophosphorus pesticides, when administered in a laboratory setting, and it remains possible that some pesticides interfere with important developmental functions of the cholinesTERase enzyme family.
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Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase.
Hong Sun,Maryann L. Shen,Maryann L. Shen,Yuan Ping Pang,Yuan Ping Pang,Oksana Lockridge,Stephen Brimijoin,Stephen Brimijoin +7 more
TL;DR: The results show that A328W/Y332A, an efficient cocaine hydrolase in vivo as well as in vitro, might promote cocaine detoxication in a clinical setting.
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Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth.
TL;DR: The hypothesis that AChE promotes neurite outgrowth, at least in part, through an adhesive function is supported.