S
Stephen C. Pflugfelder
Researcher at Baylor College of Medicine
Publications - 457
Citations - 37191
Stephen C. Pflugfelder is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Corneal epithelium & Conjunctiva. The author has an hindex of 95, co-authored 437 publications receiving 32767 citations. Previous affiliations of Stephen C. Pflugfelder include University of California & Allergan.
Papers
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Journal ArticleDOI
The definition and classification of dry eye disease: Report of the definition and classification subcommittee of the international Dry Eye WorkShop (2007)
Michael A. Lemp,Christophe Baudouin,Jules L. Baum,Murat Dogru,Gary N. Foulks,Shigeru Kinoshita,Peter R. Laibson,James P. McCulley,Juan Murube,Stephen C. Pflugfelder,Maurizio Rolando,Ikuko Toda +11 more
TL;DR: A new definition of dry eye was developed to reflect current understanding of the disease, and a three-part classification system was recommended, based on the severity of the dry eye disease, which is expected to provide a rational basis for therapy.
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The Pathology of Dry Eye: The Interaction Between the Ocular Surface and Lacrimal Glands
Michael E. Stern,Roger W. Beuerman,Robert I. Fox,Jianping Gao,Austin K. Mircheff,Stephen C. Pflugfelder +5 more
TL;DR: Although the etiologies of dry eye are varied, common to all ocular-surface disease is an underlying cytokine/receptor-mediated inflammatory process, by treating this process, it may be possible to normalize the ocular surface/lacrimal neural reflex and facilitate ocularsurface healing.
Journal Article
Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease.
Abraham Solomon,Dilek Dursun,Zuguo Liu,Zuguo Liu,Yuhuan Xie,Yuhuan Xie,Angelo Macri,Stephen C. Pflugfelder +7 more
TL;DR: The results suggest that IL-1 may play a key role in the pathogenesis of keratoconjunctivitis sicca, and the conjunctival epithelium appears to be one source of the increased concentration ofIL-1 in the tear fluid of patients with dry-eye disease.
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Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca
TL;DR: The balance of cytokines in the tear fluid and conjunctival epithelium is altered in Sjögren's syndrome and new insight into the pathogenesis of keratoconjunctivitis is provided and potential targets for therapy are provided.
Journal ArticleDOI
Evaluation of Subjective Assessments and Objective Diagnostic Tests for Diagnosing Tear-Film Disorders Known to Cause Ocular Irritation
Stephen C. Pflugfelder,Scheffer C.G. Tseng,Olga Sanabria,Hans Kell,Carlos G. Garcia,Carlos Felix,William J. Feuer,Brenda L. Reis +7 more
TL;DR: Which subjective assessments and objective tests have clinical utility as diagnostic tools in ocular irritation associated with Sjögren's syndrome—related aqueous tear deficiency, non-Sj Ögren ATD, inflammatory meibomian gland disease (MGD) associated with rosacea, and atrophic MGD are determined.