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Stephen D. Roper
Researcher at University of Miami
Publications - 100
Citations - 9351
Stephen D. Roper is an academic researcher from University of Miami. The author has contributed to research in topics: Taste & Taste bud. The author has an hindex of 49, co-authored 100 publications receiving 8750 citations. Previous affiliations of Stephen D. Roper include University of Colorado Hospital & Colorado State University.
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Journal ArticleDOI
The cell biology of taste
TL;DR: A review of the functional classes of taste cells, their cell biology, and current thinking on how taste information is transmitted to the brain is presented in this article, which reveals an elegant cellular organization within the taste bud.
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A metabotropic glutamate receptor variant functions as a taste receptor.
TL;DR: A GPCR cloned from rat taste buds and functionally expressed in CHO cells is described, which shows an unusual concentration–response relationship and the similarity of its properties to MSG taste suggests that this receptor is a taste receptor for glutamate.
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The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds
Yi Jen Huang,Yutaka Maruyama,Gennady Dvoryanchikov,Elizabeth Pereira,Nirupa Chaudhari,Stephen D. Roper +5 more
TL;DR: Results provide a mechanism to link intracellular Ca2+ release during taste transduction to secretion of afferent transmitter, ATP, from receptor cells and indicate a route for cell–cell communication and signal processing within the taste bud.
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Taste buds: cells, signals and synapses
TL;DR: New findings regarding the cellular mechanisms for detecting tastes, new data on the transmitters involved in taste processing and new studies that address longstanding arguments about taste coding are discussed.
Journal ArticleDOI
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear
Fabio Anselmi,Victor H. Hernandez,Giulia Crispino,Anke Seydel,Saida Ortolano,Stephen D. Roper,Nicoletta Kessaris,William D. Richardson,Gesa Rickheit,Mikhail A. Filippov,Hannah Monyer,Fabio Mammano +11 more
TL;DR: The results demonstrate that connexins play a dual crucial role in inner ear Ca2+ signaling: as hemichannels, they promote ATP release, sustaining long-range ICS propagation; as GJ channels, they allow diffusion of Ca2-mobilizing second messengers across coupled cells.