F
Fabio Mammano
Researcher at University of Padua
Publications - 124
Citations - 4987
Fabio Mammano is an academic researcher from University of Padua. The author has contributed to research in topics: Connexin & Cochlea. The author has an hindex of 37, co-authored 113 publications receiving 4367 citations. Previous affiliations of Fabio Mammano include National Research Council & University of Ferrara.
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Journal ArticleDOI
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear
Fabio Anselmi,Victor H. Hernandez,Giulia Crispino,Anke Seydel,Saida Ortolano,Stephen D. Roper,Nicoletta Kessaris,William D. Richardson,Gesa Rickheit,Mikhail A. Filippov,Hannah Monyer,Fabio Mammano +11 more
TL;DR: The results demonstrate that connexins play a dual crucial role in inner ear Ca2+ signaling: as hemichannels, they promote ATP release, sustaining long-range ICS propagation; as GJ channels, they allow diffusion of Ca2-mobilizing second messengers across coupled cells.
Journal ArticleDOI
p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner.
Carlotta Giorgi,Massimo Bonora,Giovanni Sorrentino,Sonia Missiroli,Federica Poletti,Jan M. Suski,Fabian Galindo Ramirez,Rosario Rizzuto,Francesco Di Virgilio,Ester Zito,Pier Paolo Pandolfi,Mariusz R. Wieckowski,Fabio Mammano,Giannino Del Sal,Paolo Pinton +14 more
TL;DR: It is demonstrated that p53 at the endoplasmic reticulum (ER) and at mitochondria-associated membranes, interacting with sarco/ER Ca2+-ATPase pumps, modulates ER–mitochondria cross-talk and, in turn, Ca2-dependent apoptosis.
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Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness.
TL;DR: It is proposed that the V84L mutation reduces metabolic coupling mediated by Ins(1,4,5)P3 to an extent sufficient to impair the propagation of Ca2+ waves and the formation of a functional syncytium.
Journal ArticleDOI
NETosis Delays Diabetic Wound Healing in Mice and Humans
Gian Paolo Fadini,Lisa Menegazzo,Mauro Rigato,Valentina Scattolini,Nicol Poncina,A Bruttocao,Stefano Ciciliot,Fabio Mammano,Catalin D. Ciubotaru,Enrico Brocco,Maria Cristina Marescotti,Roberta Cappellari,Giorgio Arrigoni,Renato Millioni,Saula Vigili de Kreutzenberg,Mattia Albiero,Angelo Avogaro +16 more
TL;DR: Using proteomics, it is found that NET components were enriched in nonhealing human DFUs and data suggest that NETosis delays DFU healing.
Journal ArticleDOI
How well do we understand the cochlea
TL;DR: The discovery of hair-cell motility has modified the view of the cochlea as a simple frequency analyser into one where it is an active non-linear filter that allows only the prominent features of acoustic signals to be transmitted to the acoustic nerve by the inner hair cells.