Showing papers by "Stephen R. Quake published in 1998"
08 Jun 1998
77 citations
26 Mar 1998
TL;DR: In this paper, microfabricated devices to size and sort microscopic biological objects, ranging from cells to single molecules of DNA, have been demonstrated using fluorescent excitation and detection.
Abstract: We have microfabricated devices to size and sort microscopic biological objects, ranging from cells to single molecules of DNA. Sizing is accomplished by fluorescent excitation and detection. The devices are fabricated in a silicone elastomer using a replica method. Single molecules of DNA have been sized to 10 percent accuracy, and manipulation of E. Coli cells has been demonstrated.
33 citations