Steve W. Cole

TL;DR: The video-game intervention significantly improved treatment adherence and indicators of cancer-related self-efficacy and knowledge in adolescents and young adults who were undergoing cancer therapy.

TL;DR: Genome-wide transcriptional profiling in healthy adults who were either low or high in socioeconomic status (SES) in early life suggests that low early-life SES programs a defensive phenotype characterized by resistance to glucocorticoid signaling, which facilitates exaggerated adrenocortical and inflammatory responses.

TL;DR: Sleep loss induces a functional alteration of the monocyte proinflammatory cytokine response, which alters molecular processes that drive cellular immune activation and induce inflammatory cytokines; mapping the dynamics of sleep loss on molecular signaling pathways has implications for understanding the role of sleep in altering immune cell physiologic characteristics.

TL;DR: In this article, the authors analyzed genome-wide transcriptional activity in people who chronically experienced high versus low levels of subjective social isolation (loneliness) to assess alterations in the activity of transcription control pathways that might contribute to increased adverse health outcomes in social isolates.

TL;DR: The value of a disease-centered approach that "reverse engineers" adverse health outcomes into their specific biological determinants and then identifies psychologically modulated neuroendocrine and immunologic dynamics that modulate those pathological processes at the cellular and molecular levels is emphasized.