Steven H. Reynolds

TL;DR: The B6C3F1 mouse liver may provide a sensitive assay system to detect various classes of proto-oncogenes that are susceptible to activation by carcinogenic insult and will provide information at a molecular level to aid in the use of rodent carcinogenesis data for risk assessment.

TL;DR: It is demonstrated that some MWCNT exposures promote the growth and neoplastic progression of initiated lung cells in B6C3F1 mice, indicating that caution should be used to limit human exposures to M WCNT.

TL;DR: A marked difference in the presence of activated oncogenes in spontaneous rat tumors versus spontaneous mouse liver tumors was observed in this study, suggesting the B6C3F1 mouse liver system might provide a very sensitive assay not only for assessing the potential of a chemical to activate a cellular proto-oncogene, but also for detecting various classes of proto- oncogenees that are susceptible to mutational activation.

TL;DR: These results are the first to report disruption of the mitotic spindle by single‐walled carbon nanotubes, and the nanotube bundles are similar to the size of microtubules that form the mitotics and may be incorporated into the mitosis spindle apparatus.

TL;DR: Stable transfer of DLC-1 abolished tumorigenicity in nude mice of two cell lines, suggesting that DLC- 1 plays a role in NSCLC by acting as a bona fide new tumor suppressor gene.