Steven S. Matsumoto

TL;DR: These compounds were found to be inducers of cellular differentiation of HL-60 cells in the range of 30-60 microM and were comparable to ribavirin in this regard.

TL;DR: A novel and direct synthesis of the antiviral and antitumor agent 4-amino-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine (ARPP, 8) and its alpha-anomer (11) has been developed.

TL;DR: Tubercidin (7-deazaadenosine, 1a) and several 6-chlorotuber-Cidin derivatives were synthesized including 4-amino-6-chloro-7-β-D-ribofuranosylpyrrolo[2,3-d]pyrimidine-3′,5′-cycyclic phosphate 9 as discussed by the authors.

TL;DR: Observations establish these low-molecular-weight compounds as interesting probes for the study of stimulus-response coupling in phagocytes as well as suggesting an important role for cytokines/lymphokines in the nucleoside-induced phagocyte activation in vivo.

TL;DR: The comparative antileukemic activities of 21 novel nucleosides were determined in vitro by using cultured L1210 cells and analyzed for structure-related efficacy by a computer-aided receptor modeling method (REMOTEDISC), thereby establishing the major contributions of these three molecular entities to overall antitumor activity.