Steven W. J. Lamberts

TL;DR: Physical changes during aging have been considered physiologic, but there is evidence that some of these changes are related to this decline in hormonal activity, and increasing blood hormone levels in aging individuals to those found during mid-adult life has not been uniformly proven to be safe and of benefit.

TL;DR: Experimental studies show that chronic administration of somatostatin analogs causes growth inhibition of a number of (transplantable) tumors in animals, including chondrosarcomas, pancreatic, prostatic, breast, and pituitary cancers.

TL;DR: Criteria to define active acromegaly and disease control were agreed, and several significant changes were made to the 2000 guidelines.

TL;DR: Bioavailable T, E1, total E2, and bioavailable E2 all decrease with age in healthy old men, and non-SHBG-bound T seems to be the best parameter for serum levels of bioactive T, which seems to play a direct role in the various physiological changes that occur during aging.

TL;DR: Standard therapy for the latter patients consists of the administration of high doses of corticosteroids during any severe illness and perioperatively, and replacement doses or high doses in patients with severe illness, especially those with multiorgan-system diseases.