S
Steven W. Kessler
Researcher at National Institutes of Health
Publications - 32
Citations - 5615
Steven W. Kessler is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Stem cell & CD34. The author has an hindex of 17, co-authored 28 publications receiving 5586 citations. Previous affiliations of Steven W. Kessler include Henry M. Jackson Foundation for the Advancement of Military Medicine & United States Department of the Navy.
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Journal Article
Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.
TL;DR: Bacterial adsorbent not only had a distinct advantage in speed of antigen isolation, but analyses by polyacrylamide gel electrophoresis in SDS also revealed consistently higher antigen recoveries, lower levels of background radioactivity, and an absence of other cell components which may nonspecifically bind to and complicate analyses using conventional immune precipitates.
Journal ArticleDOI
Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.
Robert E. Donahue,Steven W. Kessler,David M. Bodine,Kevin T. McDonagh,Cynthia E. Dunbar,S Goodman,Brian A. Agricola,Ellen Byrne,Mark Raffeld,R Moen +9 more
TL;DR: It is concluded that replication-competent viruses arising from producer cells making Retroviral vectors can be pathogenic in primates, which underscores the importance of carefully screening retroviral producer clones used in human trials to exclude contamination with replication- competent virus.
Journal Article
Cell membrane antigen isolation with the staphylococcal protein A-antibody adsorbent.
TL;DR: Adsorption of antigen-antibody complexes is quantitative when protein A sites are provided in excess over antiserum IgG sites, and this obviates the need for equivalence point titrations for optimal precipitation necessary with alternative double antibody techniques.
Journal ArticleDOI
Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow
Thomas M. Folks,Steven W. Kessler,Jan M. Orenstein,Jesse S. Justement,Elaine S. Jaffe,Anthony S. Fauci +5 more
TL;DR: It is indicated that the bone marrow may serve as a potentially important reservoir of HIV-1 in the body and the possible cause of certain of the observed hematologic abnormalities in HIV-2 infection is unknown.
Journal Article
Demonstration of the Origin of Human Mast Cells from CD34+ Bone Marrow Progenitor Cells
TL;DR: It is concluded that both human mast cells and basophils arise from CD34+ human progenitor cells.