S
Stone R Streeter
Researcher at Johns Hopkins University School of Medicine
Publications - 5
Citations - 53
Stone R Streeter is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Obstructive sleep apnea & Leptin. The author has an hindex of 3, co-authored 5 publications receiving 17 citations. Previous affiliations of Stone R Streeter include Johns Hopkins University.
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Journal ArticleDOI
Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db/db mice.
Huy Pho,Slava Berger,Carla Freire,Lenise Jihe Kim,Mi Kyung Shin,Stone R Streeter,Nishitha Hosamane,Meaghan E Cabassa,Frederick Anokye-Danso,Olga Dergacheva,Mateus R. Amorim,Thomaz Fleury-Curado,Jonathan C. Jun,Alan R. Schwartz,Alan R. Schwartz,Rexford S. Ahima,David Mendelowitz,Vsevolod Y. Polotsky +17 more
TL;DR: In this article, the authors showed that Ad-LepR b infection resulted in LepR b expression in the dorsomedial hypothalamus (DMH) neurons in a similar fashion to wildtype mice.
Journal ArticleDOI
Intranasal Leptin Prevents Opioid-induced Sleep-disordered Breathing in Obese Mice
Carla Freire,Carla Freire,Huy Pho,Lenise Jihe Kim,Xin Wang,Jhansi Dyavanapalli,Stone R Streeter,Thomaz Fleury-Curado,Thomaz Fleury-Curado,Luiz Ubirajara Sennes,David Mendelowitz,Vsevolod Y. Polotsky +11 more
TL;DR: In vitro studies demonstrated that DAMGO reduced the frequency of excitatory post-synaptic currents in hypoglossal motoneurons and that application of leptin restoredexcitatory synaptic neurotransmission, suggesting that intranasal leptin may prevent opioid respiratory depression during sleep in obese patients receiving opioids without reducing analgesia.
Journal ArticleDOI
Designer Receptors Exclusively Activated by Designer Drugs Approach to Treatment of Sleep-disordered Breathing
Thomaz Fleury Curado,Thomaz Fleury Curado,Huy Pho,Carla Freire,Carla Freire,Mateus R. Amorim,Mateus R. Amorim,Jordi Bonaventura,Lenise Jihe Kim,Lenise Jihe Kim,Rachel Lee,Meaghan E Cabassa,Stone R Streeter,Luiz G.S. Branco,Luiz Ubirajara Sennes,Kenneth Fishbein,Richard G. Spencer,Alan R. Schwartz,Alan R. Schwartz,Michael J Brennick,Michael Michaelides,David D. Fuller,Vsevolod Y. Polotsky +22 more
TL;DR: It is concluded that following intralingual administration of AAV9-DREADD, J60 can activate the genioglossus muscle, and improve pharyngeal patency and breathing during sleep.
Posted ContentDOI
Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db/db mice
Huy Pho,Slava Berger,Carla Freire,Lenise Jihe Kim,Mi Kyung Shin,Stone R Streeter,Nishitha Hosamane,Meaghan E Cabassa,Frederick Anokye-Danso,Olga Dergacheva,Mateus R. Amorim,Thomaz Fleury-Curado,Jonathan C. Jun,Alan R. Schwartz,Alan R. Schwartz,Rexford S. Ahima,David Mendelowitz,Vsevolod Y. Polotsky +17 more
TL;DR: It is concluded that leptin stimulates breathing and treats obesity related hypoventilation acting on LepRb-positive neurons in the DMH.
Journal ArticleDOI
Intranasal leptin prevents opioid-induced respiratory depression in obesity
Carla Freire,Huy Pho,Lenise Jihe Kim,Xin Wang,Jhansi Dyavanapalli,Olga Dergacheva,Stone R Streeter,Thomaz Fleury-Curado,Luiz Ubirajara Sennes,Vsevolod Y. Polotsky +9 more
TL;DR: In this article, compositions and methods of treating opioid-induced respiratory depression in a subject in need thereof, the method comprising administering leptin, were described. But the method was not discussed.