M
Michael Michaelides
Researcher at National Institute on Drug Abuse
Publications - 88
Citations - 3742
Michael Michaelides is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 28, co-authored 65 publications receiving 2777 citations. Previous affiliations of Michael Michaelides include Brookhaven National Laboratory & Stony Brook University.
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Journal ArticleDOI
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.
Juan Gómez,Jordi Bonaventura,Wojciech G. Lesniak,William B. Mathews,Polina Sysa-Shah,Lionel A. Rodriguez,Randall J. Ellis,Christopher T. Richie,Brandon K. Harvey,Robert F. Dannals,Martin G. Pomper,Antonello Bonci,Michael Michaelides,Michael Michaelides +13 more
TL;DR: Radioligand receptor occupancy measurements and in vivo positron emission tomography are used to show that DREADDs expressed in the brain are not activated by the designer compound CNO (clozapine N-oxide), instead, they areactivated by the CNO metabolite clozapines, a drug with multiple endogenous targets.
Journal ArticleDOI
The Neuroscience of Drug Reward and Addiction.
TL;DR: Treatment interventions intended to reverse neuroadaptations that result in an impaired prefrontal top-down self-regulation that favors compulsive drug-taking against the backdrop of negative emotionality and an enhanced interoceptive awareness of "drug hunger" show promise as therapeutic approaches for addiction.
Journal ArticleDOI
Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.
Henrietta Szutorisz,Jennifer A. DiNieri,Eric S. Sweet,Gabor Egervari,Michael Michaelides,Jenna M. Carter,Yanhua Ren,Michael L. Miller,Robert D. Blitzer,Yasmin L. Hurd +9 more
TL;DR: Adolescent exposure to Δ9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, results in behavioral and neurobiological abnormalities in the subsequent generation of rats as a consequence of parental germline exposure to the drug.
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Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in‐vivo μPET imaging ([11C] raclopride) and in‐vitro ([3H] spiperone) autoradiography
Panayotis K. Thanos,Panayotis K. Thanos,Michael Michaelides,Yiannis K. Piyis,Gene-Jack Wang,Nora D. Volkow +5 more
TL;DR: The ARG finding of an attenuation of the age‐related loss of D2R binding corroborates previous studies of the salutary effects of food restriction in the aging process and suggests that the differences in dopamine activity and D1R levels between Ob and Le Zucker rats are modulated by access to food.
Journal ArticleDOI
Progress towards a public chemogenomic set for protein kinases and a call for contributions
David H. Drewry,Carrow I. Wells,David M. Andrews,Richard Angell,Hassan Al-Ali,Alison D. Axtman,Stephen J. Capuzzi,Jonathan M. Elkins,Peter Ettmayer,Mathias Frederiksen,Opher Gileadi,Nathanael S. Gray,Alice Hooper,Stefan Knapp,Stefan Laufer,Ulrich Luecking,Michael Michaelides,Susanne Müller,Eugene N. Muratov,R. Aldrin Denny,Kumar Singh Saikatendu,Daniel K. Treiber,William J. Zuercher,Timothy M. Willson +23 more
TL;DR: This manuscript shares progress towards generation of a comprehensive kinase chemogenomic set (KCGS), releases kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outlines a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases.