https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Resveratrol, trans-3,5,4'-trihydroxystilbene, was first isolated in 1940 as a constituent of the roots of white hellebore (Veratrum grandiflorum O. Loes), but has since been found in various plants, including grapes, berries and peanuts. Besides cardioprotective effects, resveratrol exhibits anticancer properties, as suggested by its ability to suppress proliferation of a wide variety of tumor cells, including lymphoid and myeloid cancers; multiple myeloma; cancers of the breast, prostate, stomach, colon, pancreas, and thyroid; melanoma; head and neck squamous cell carcinoma; ovarian carcinoma; and cervical carcinoma. The growth-inhibitory effects of resveratrol are mediated through cell-cycle arrest; upregulation of p21Cip1/WAF1, p53 and Bax; down-regulation of survivin, cyclin D1, cyclin E, Bcl-2, Bcl-xL and clAPs; and activation of caspases. Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA. These activities account for the suppression of angiogenesis by this stilbene. Resveratrol also has been shown to potentiate the apoptotic effects of cytokines (e.g., TRAIL), chemotherapeutic agents and gamma-radiation. Phamacokinetic studies revealed that the target organs of resveratrol are liver and kidney, where it is concentrated after absorption and is mainly converted to a sulfated form and a glucuronide conjugate. In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression. Besides chemopreventive effects, resveratrol appears to exhibit therapeutic effects against cancer. Limited data in humans have revealed that resveratrol is pharmacologically quite safe. Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer.

/pdf/role-of-resveratrol-in-prevention-and-therapy-of-cancer-tq57uztzep.pdf

Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies

13C NMR spectra of pentacyclic triterpenoids--a compilation and some salient features

Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology.

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.

https://downloads.hindawi.com/journals/bmri/2013/963248.pdf

Review on natural coumarin lead compounds for their pharmacological activity

Testosterone and 19-norethisterone are smoothly esterified by some hindered carboxylic acids in pyridine containing benzenesulphonyl chloride.

Convenient preparation of esters of testosterone and 19-norethisterone with hindered acids

Calophyllum bracteatum, C. calaba(var. calaba), C. moonii(=C. soulattri), C. thwaitesii, C. trapezifolium, C. Walkeri, and C. zeylanicum(=C. lankaensis) have been examined for their bark acids. A new acid, calozeylanic acid, has been isolated from three species and has been identified as (2R,3R)-2,3-dimethyl-5-hydroxy-6-(3-methylbutyl)-6-(3,7-dimethylocta-3,6-dienyl)-8-(2-carboxy-1-phenylethyl)-2,3,6,7-tetrahydrobenzopyran-4,7-dione. Four species were found to be different, having the enantioner of apetalic acid, isoapetalic acid and a minor acid identified as the structural isomer of the latter.

Bark acids of seven Calophyllum species (Guttiferae)

The rare alkaloid telobine (3) has been isolated from the bark of the new Daphnandra sp., D. apatela Schodde, together with five new alkaloids. The structures of three of these, apateline (1), 1,2-dehydroapateline (6) and 1,2-dehydrotelobine (5), have been determined.

Alkaloids of Daphnandra apatela

Pachyovatamine, a bisbenzylisoquinoline alkaloid, and other alkaloids from Pachygone ovata

Alcaloids were extracted from defatted bark of Litsea gardneni and from leaves of Actinodaphne speciosa. They were tested for antibacterial activity against Escherichia coli and staphylococcus aureus. Activity was observed only for laurolitsine

Subramaniam Sotheeswaran

Papers

Convenient preparation of esters of testosterone and 19-norethisterone with hindered acids

Bark acids of seven Calophyllum species (Guttiferae)

Alkaloids of Daphnandra apatela

Pachyovatamine, a bisbenzylisoquinoline alkaloid, and other alkaloids from Pachygone ovata

Aporphine alkaloids from Litsea gardneri and Actinodaphne speciosa.