The epidermis-regenerating effect of various chitin derivatives is revealed and a drug for the remedy or treatment of wounds which is effectively usable clinically is provided. It has become obvious that N-acetyl-D-glucosamine has the effect of accelerating the proliferation of epidermal keratinocytes. Thus, an epidermal kerationocyte growth accelerator containing N-acetyl-D-glcosamine is provided. Also provided are a regeneration accelerator and a protective agent for the epithelium, skin, or corium.

Drug for remedy or treatment of wound

Personal care compositions containing at an alpha-glucan and/or beta-glucan; at least one additional skin and/or hair care active selected from the group consisting of sugar amine, vitamin B3, retinoids, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), menthyl anthranilate, cetyl pyridinium chloride, ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, tetrahydrocurcumin, their derivatives, their precursors, and combinations thereof; and a dermatologically acceptable carrier.

Personal care compositions comprising alpha-glucans and/or beta-glucans

External skin compositions characterized by containing at least one member selected from the group consisting of N-acetylglucosamine, retinoid and provitamin A. These compositions have an effect of promoting epidermal hyaluronic acid production and thus make it possible to sustain the tension and moistness of the skin.

External skin compositions

An acetylated N-acetylglucosamine derivative represented by the following general formula (1) and a hyaluronic acid production promoter containing the same and a skin preparation for external use containing the same. General formula (1): wherein R1 represents hydrogen or C2-18 alkyl; R2, R3 and R4 may be either the same or different and each represents hydrogen or C2-18 acyl; and the stereostructure at the 1-position may be either α- or β-structure, provided that R1, R2, R3 and R4 do not represent hydrogen at the same time. It is intended to provide an easily available hyaluronic acid production promoter and a skin preparation for external use by which the production of hyaluronic acid can be promoted in the skin and thus the skin can be maintained in a firm and moisten state so that it is expected that the human skin can be prevented from aging.

N-acetylglucosamine derivatives and use thereof

PROBLEM TO BE SOLVED: To provide a photoaging amelioration agent for skin and to provide an external preparation for skin having excellent effect to ameliorate the photoaging symptoms such as the wrinkles and sagging of the skin. SOLUTION: The invention provides an external preparation for skin having excellent effect to ameliorate the photoaging symptoms such as the wrinkles and sagging of the skin and comprising a photoaging amelioration agent for skin for external use compounded with a glycosaminoglycan-relating substance, wherein the glycosaminoglycan-relating substance is a substance constituting the sugar chain of proteoglycan and/or its derivative and comprising one or more substances selected from D-glucosamine hydrochloride, N-acetyl-D-glucosamine, D-xylose and sodium chondroitin sulfate. COPYRIGHT: (C)2008,JPO&INPIT

Photoaging amelioration agent for skin

PROBLEM TO BE SOLVED: To obtain the subject agent which can increase the hyaluronic acid content of the horny layer to optimize the water environment and hardness of the horny layer, allows to expect an effect for preventing rough skins and wrinkles, is stable in preparations, and is useful for skin cosmetics, by including N-acetylglucosamine. SOLUTION: This agent for increasing the hyaluronic acid content of a horny layer comprises N-acetylglucosamine. The agent is preferably added to a skin cosmetic preferably in an amount of 0.001 to 10%, especially preferably 0.01 to 5%, based on the total amount of the cosmetic composition. The agent may preferably further be compounded with a polyhydric alcohol such as 1,3-butylene glycol, a vitamin derivative such as an ascorbic acid phosphoric acid ester salt, an anionic surfactant such as N-stearoyl-L-glutamic acid salt, and so on.

Agent for increasing hyaluronic acid content of horny layer

PROBLEM TO BE SOLVED: To obtain an epidermal cornification accelerator which contains a substance relating to silicic acid, has an action to promote the cornification of epidermal cells to restore the barrier function of skin and is effective for atopic dermatitis, psoriasis, xeroderma, skin roughening, dandruff, lip roughening and the like. SOLUTION: This epidermal cornification accelerator contains 0.1-99wt.%, preferably 5-60wt.% of a substance relating to silicic acid, for example, silicic acid, metasilicic acid, orthosilicic acid, as an active ingredient. When this cornification accelerator is adapted to cosmetics or the like, an acid such as citric acid is preferably employed to adjust the pH to 2-10. The does as a skin preparation for external use or as a cosmetic is percutaneously 1-50mg every application in a formulation. When a bath article is formulated, the dose of the accelerator is 1-5,000mg/l in the bath water. When it is added to a cell culture system, the dose is 1-100,000μM.

Sueshige Yasuda

Papers

Agent for increasing hyaluronic acid content of horny layer

Epidermal cornification accelerator