Showing papers by "Sujay Ghosh published in 2017"

Combined association of Presenilin-1 and Apolipoprotein E polymorphisms with maternal meiosis II error in Down syndrome births

Abstract: Alzheimer's disease and Down syndrome often exhibit close association and predictively share common genetic risk-factors. Presenilin-1 (PSEN-1) and Apolipoprotein E (APOE) genes are associated with early and late onset of Alzheimer's disease, respectively. Presenilin −1 is involved in faithful chromosomal segregation. A higher frequency of the APOE e4 allele has been reported among young mothers giving birth to Down syndrome children. In this study, 170 Down syndrome patients, grouped according to maternal meiotic stage of nondisjunction and maternal age at conception, and their parents were genotyped for PSEN-1 intron-8 and APOE polymorphisms. The control group consisted of 186 mothers of karyotypically normal children. The frequencies of the PSEN-1 T allele and TT genotype, in the presence of the APOE e4 allele, were significantly higher among young mothers (< 35 years) with meiosis II nondisjunction than in young control mothers (96.43% vs. 65.91% P = 0.0002 and 92.86% vs. 45.45% P < 0.0001 respectively) but not among mothers with meiosis I nondisjunction. We infer that the co-occurrence of the PSEN-1 T allele and the APOE e4 allele associatively increases the risk of meiotic segregation error II among young women.

Bisphenol A: Understanding Its Health Effects from the Studies Performed on Model Organisms

Abstract: Bisphenol A [4,4′‐(propane‐2,2‐diyl)diphenol] (abbreviated as BPA) is a synthetic xenoestro‐ genic chemical and endocrine disruptor. It is a most common plasticizer that is used widely to produce epoxy resin and polycarbonate plastics, enters the living system through food and water contamination and generates health hazards. Researches are being conducted to explore the adversity that BPA exerts in living body, and for this reason, model organisms are of scientific choice. Rodents, zebrafish, Drosophila, nematodes, crustaceans and echino‐ derms are being used for monitoring the effect of BPA on their life history traits, nervous system, endocrine system, reproductive systems, behaviour, etc., which could help us to anticipate what kind of challenges BPA is putting in human life. This systematic review is focused on the latest research trend on BPA toxicity on different model organisms.

Faunal account of the predatory mites (Acari: Cunaxidae and Phytoseiidae) from the Agri-horticultural crops of south Bengal with three new records from India

Abstract: The paper deals with the study of predatory mites which was undertaken from January, 2015 to March, 2017 to explore the predatory mite fauna from different agri-horticultural crops in 11 southern districts of West Bengal. A total number of 33 species of predatory mites were recorded with their predatory habits, prey preference, impact on prey population and the inhabiting plants among which 10 species under 2 genera are of family Cunaxidae and 23 species under 7 genera are of family Phytoseiidae. Phytoseiids were found more diversed and abundant than family Cunaxidae. One species namely Amblyseius impressus of Phytoseiidae and two species of Cunaxidae viz., Cunaxa evansi and Dactyloscirus fuscus were reported first time from India. The current investigation reports the diversity of predatory mites harbouring various types of agriculturally important crops of South Bengal with their distribution, habitat specificity, prey preference and effective predatory behaviour.

Rare Intronic Variations in TP73 Gene Found in Patients with Alzheimer’s Disease

Abstract: TP73 gene encodes p73 transcription factor, crucial for neurogenesis and neuronal health maintenance. In aging brain, p73 haploinsufficiency increases deposition of tau aggregates, hallmark...