S
Sujeewa Ranatunga
Researcher at New Mexico State University
Publications - 16
Citations - 513
Sujeewa Ranatunga is an academic researcher from New Mexico State University. The author has contributed to research in topics: Unfolded protein response & AKT1. The author has an hindex of 9, co-authored 13 publications receiving 413 citations. Previous affiliations of Sujeewa Ranatunga include University of South Florida.
Papers
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Journal ArticleDOI
Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.
Chih-Hang Anthony Tang,Joseph A. Zundell,Sujeewa Ranatunga,Cindy Lin,Yulia Nefedova,Juan R. Del Valle,Chih-Chi Andrew Hu +6 more
TL;DR: It is shown that the IRE-1/XBP-1 pathway functions downstream of STING and that STING agonists selectively trigger mitochondria-mediated apoptosis in normal and malignant B cells, implying that prolonged activation of STing can lead to apoptosis.
Journal ArticleDOI
Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival
Chih-Hang Anthony Tang,Sujeewa Ranatunga,Crystina L. Kriss,Christopher L. Cubitt,Jianguo Tao,Javier Pinilla-Ibarz,Juan R. Del Valle,Chih-Chi Andrew Hu +7 more
TL;DR: Data indicate that targeting XBP-1 has potential as a treatment strategy, not only for multiple myeloma, but also for mature B cell leukemia and lymphoma.
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Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.
Sujeewa Ranatunga,Chih-Hang Anthony Tang,Chang Won Kang,Crystina L. Kriss,Bernhard J. Kloppenburg,Chih-Chi Andrew Hu,Juan R. Del Valle +6 more
TL;DR: The synthesis and biological evaluation of novel chromenone-based covalent inhibitors of IRE-1 led to the identification of 30 as a potent inhibitor of Ire-1 RNase activity and XBP-1s expression in wild type B cells and human mantle cell lymphoma cell lines.
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Total Synthesis of the Putative Structure of Lucentamycin A
TL;DR: A rapid and stereoselective enolate-Claisen rearrangement provides access to the 4-ethylidene-3-methylproline (Emp) subunit of lucentamycin A and suggests the need for structural revision.
Journal ArticleDOI
β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching
Chang Won Kang,Matthew P. Sarnowski,Sujeewa Ranatunga,Lukasz Wojtas,Rainer Metcalf,Wayne C. Guida,Juan R. Del Valle +6 more
TL;DR: Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations of tetrahydropyridazinedione backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint.