The invention relates to compounds of formula (I) wherein R1 is aryl or heteroaryl, wherein the aryl and heteroaryl groups may be unsubstituted or substituted by one to three substituents, selected from the group consisting of cycloalkyl, phenyl, phenyloxy, benzyl, benzyloxy, halogen, lower alkyl, lower alkoxy, heteroaryl, piperidin-1-yl or by lower alkyl substituted by halogen, or is aryl or heteroaryl wherein at least one hydrogen atom is replaced by deuterium or tritium; R2 is hydrogen, lower alkyl or is benzyl unsubstituted or substituted by alkoxy or halogen; or R1 and R2 form together with the N-atom to which they are attached 2,3-dihydroindol-1-yl or 3,4-dihydro-quinolin-1-yl; R3 is hydrogen or lower alkyl or to a pharmaceutically suitable acid addition salt thereof for the treatment of CNS disorders.

2-Aminooxazolines as TAAR1 ligands

Synthesis, DFT calculations, electronic structure, electronic absorption spectra, natural bond orbital (NBO) and nonlinear optical (NLO) analysis of the novel 5-methyl-8H-benzo[h]chromeno[2,3-b][1,6] naphthyridine-6(5H),8-dione (MBCND)

The present invention is directed to novel benzopyran derivatives of formula (I), pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.

Novel benzopyran derivatives as potassium channel openers

A new series of chromeno[2,3-b]pyridines was efficiently synthesized via chemical transformations of 6-methylchromone-3-carbonitrile with some methylene-active compounds bearing –CH2–CN and –CH2–CO– moieties. Some heteroannelated chromeno[2,3-b]pyridines were also synthesized. The structures of the new synthesized products were deduced on the basis of their analytical and spectral data.

Synthesis of Some Novel Heteroannelated Chromones by Basic Rearrangement of 6-Methylchromone-3-Carbonitrile

Synthesis of Heteroannulated Chromeno[2,3‐b]Pyridines: DBU Catalyzed Reactions of 2‐Amino‐6‐methylchromone‐3‐Carboxaldehyde with Some Heterocyclic Enols and Enamines

We attempted to replace a benzopyran ring of 4-[(N-imidazol-2-ylmethyl)-4-chloroanilino]benzopyran, previously discovered as anti-angiogenic agent with antitumor activity, with pyranopyridines. The [3,2-c]-, [3,2-b]-, [2,3-c]-, and [2,3-b]-pyranopyridines with -(imidazol-2-ylmethyl)aniline moiety at the 4-position, were synthesized respectively, and evaluated for primary anti-angiogenic properties through primary cultured HUVEC tube formation assay. From this study, we found that the pyranopyridine ring, especially [3,2-b]- and [2,3-c]-isomer, can replace the benzopyran ring of the compound 1 and can be optimized through the introduction of substituents both on the pyranopyridine ring and the aniline moiety for the identification of a novel anti-angiogenic agent.

http://koreascience.or.kr:80/article/JAKO200502727010838.pdf

Sun Mi Chae

Papers

4-[(N-Imidazol-2-ylmethyl)anilino]pyranopyridine Analogs as Novel Anti-Angiogenic Agents

4-[(N-Imidazol-2-ylmethyl)anilino]pyranopyridine Analogues as Novel Antiangiogenic Agents.