S
Sung Nain Tseng
Researcher at Chang Gung University
Publications - 4
Citations - 349
Sung Nain Tseng is an academic researcher from Chang Gung University. The author has contributed to research in topics: Virus & Orthomyxoviridae. The author has an hindex of 4, co-authored 4 publications receiving 315 citations. Previous affiliations of Sung Nain Tseng include National Health Research Institutes.
Papers
More filters
Journal ArticleDOI
Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.
Jiann Yih Yeh,Mohane Selvaraj Coumar,Jim-Tong Horng,HY Shiao,HY Shiao,Fu Ming Kuo,Hui Ling Lee,In Chun Chen,Chun Wei Chang,Wen Fang Tang,Sung Nain Tseng,Chi Jene Chen,Shin-Ru Shih,John T.A. Hsu,John T.A. Hsu,Chun-Chen Liao,Chun-Chen Liao,Yu-Sheng Chao,Hsing Pang Hsieh +18 more
TL;DR: Preliminary mechanistic studies suggest that these compounds act as anti-influenza agents by inhibiting ribonucleoprotein (RNP) complex associated activity and have the potential to be developed further, which could form the basis for developing additional defense against influenza pandemics.
Journal ArticleDOI
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity
Shin-Ru Shih,Tzu Yun Chu,Gadarla Randheer Reddy,Sung Nain Tseng,Hsiun Ling Chen,Wen Fang Tang,Ming Sian Wu,Jiann Yih Yeh,Yu-Sheng Chao,John T.A. Hsu,John T.A. Hsu,Hsing Pang Hsieh,Jim-Tong Horng +12 more
TL;DR: BPR1P0034 is the first pyrazole-based anti-influenza compound ever identified and characterized from high throughput screening to show potent (sub-μM) antiviral activity, and results suggest that it targets the virus during viral uncoating or viral RNA importation into the nucleus.
Journal ArticleDOI
Aurintricarboxylic acid inhibits influenza virus neuraminidase.
Hui Chen Hung,Ching-Ping Tseng,Jinn-Moon Yang,Yi Wei Ju,Sung Nain Tseng,Yen Fu Chen,Yu-Sheng Chao,Hsing Pang Hsieh,Shin-Ru Shih,Shin-Ru Shih,John T.A. Hsu,John T.A. Hsu +11 more
TL;DR: It is found that aurintricarboxylic acid (ATA) is a potent inhibitor of NA activity of both group-1 and group-2 influenza viruses with IC50s values at low micromolar concentrations.
Journal ArticleDOI
BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses
Shin-Ru Shih,Jim-Tong Horng,Leo L.M. Poon,Tzu-Chun Chen,Jiann Yih Yeh,Hsing Pang Hsieh,Sung Nain Tseng,Chiayn Chiang,Wan Ling Li,Yu-Sheng Chao,John T.A. Hsu,John T.A. Hsu +11 more
TL;DR: BPR2-D2 was identified as a novel inhibitor of influenza virus and may target viral RNPs that are responsible for viral RNA synthesis that is driven by influenza viral RNP in a transfection assay.