Susan Benard

TL;DR: It is concluded that ERFE suppresses hepcidin by inhibiting hepatic BMP/SMAD signaling via preferentially impairing an evolutionarily closely related BMP subgroup of BMP5, BMP6, and BMP7.

TL;DR: The structure of the ligand-binding ectodomain of human Lingo-1 has a bimodular, kinked structure composed of leucine-rich repeat (LRR) and immunoglobulin (Ig)-like modules and biophysical analysis of its solution properties reveals that in the crystals and in solution Linge-1 persistently associates with itself to form a stable tetramer, suggesting a model for protein assembly on the membrane.

TL;DR: The development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART®) bispecific molecule against P-cadherin and CD3 that demonstrates antibody-like properties and in vivo anti-tumor efficacy in a human colorectal/human peripheral blood mononuclear cell (PBMC) co-mix xenograft mouse model is reported.

TL;DR: An X-ray costructure of a promising small molecule in this library complexed with ZipA(185-328) revealed that the compound binds to the same hydrophobic pocket as the FtsZ(367-383) peptide.

TL;DR: Targeting PSGL-1 with a blocking Ab that has diminished Fc-mediated effector function is a simple and effective strategy that provides the rationale for novel therapeutic approaches to maximize the organ donor pool through the safer use of liver transplants despite prolonged periods of cold ischemia.