S
Susan C. Wheatley
Researcher at University of Queensland
Publications - 5
Citations - 2301
Susan C. Wheatley is an academic researcher from University of Queensland. The author has contributed to research in topics: Regulation of gene expression & SOX9. The author has an hindex of 5, co-authored 5 publications receiving 2197 citations.
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Journal ArticleDOI
SOX9 directly regulates the type-II collagen gene.
Donald M. Bell,Keith K.H. Leung,Susan C. Wheatley,Ling Jim Ng,Sheila Zhou,Kam Wing Ling,Mai Har Sham,Peter Koopman,Peter Koopman,Patrick P.L. Tam,Kathryn S.E. Cheah +10 more
TL;DR: It is shown that SOX9 protein binds specifically to sequences in the first intron of human COL2A1, the gene encoding type-ll collagen, which implicate abnormal regulation of COL2a1 during chondrogenesis as a cause of the skeletal abnormalities associated with campomelic dysplasia.
Journal ArticleDOI
A male-specific role for SOX9 in vertebrate sex determination
TL;DR: The conservation of sexually dimorphic expression in two vertebrate classes which have significant differences in their sex determination mechanisms, points to a fundamental role for SOX9 in testis determination in vertebrates.
Journal ArticleDOI
SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse
Ling-Jim Ng,Susan C. Wheatley,George E.O. Muscat,John Conway-Campbell,Jo Bowles,Edwina Wright,Donald M. Bell,Patrick P.L. Tam,Kathryn S.E. Cheah,Peter Koopman +9 more
TL;DR: It is shown that mouse SOX9 protein is able to bind to a SOX/SRY consensus motif in DNA and contains a modular transcriptional activation domain, consistent with a role forSOX9 as a transcription factor acting on genes involved in cartilage development.
Journal ArticleDOI
Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryos.
TL;DR: The results are consistent with the concept that the activity of genes on the XSxra fragment is essential for the differentiation of Sertoli cells and the morphogenesis of the testis, but not for premeiotic differentiation of germ cells in sex-reversed mice.