Susan E. Lanzendorf

TL;DR: Oocytes from 5 of 11 patients microinjected with human spermatozoa demonstrated successful pronuclear formation and correlated with the incidence of pregnancy in these patients transferred with same-source oocytes inseminated by standard protocols, promoting the supposition of clinical feasibility of assisted fertilization by sperm microinjection.

TL;DR: The results suggest that cryopreservation of the prophase I human oocyte does not significantly increase abnormalities in the resulting meiotic spindle.

TL;DR: Intracytoplasmic sperm injection offers a new and powerful therapeutic option to treat couples with severe male factor infertility associated with a variety of sperm abnormalities and an adequate female age is a pivotal factor determining a successful outcome.

TL;DR: Prophase I oocytes from stimulated IVF cycles are able to survive cryopreservation and resume meiosis to achieve full nuclear maturation post-thaw and retain the same capacity for fertilization and development as control oocytes.

TL;DR: Monitoring of the expression of the mRNAs of DNA methyltransferases, methyl‐CpG‐binding domain proteins, and CpG binding protein in a developmental series of amplified cDNA samples derived from staged human ovarian follicles, oocytes, preimplantation embryos, human embryonic stem (hES) cells and in similar murine c DNA samples demonstrated an association of the DNMT3b1 transcript variant with totipotent and pluripotent human cells.