S
Susan J. Murch
Researcher at University of British Columbia
Publications - 169
Citations - 9261
Susan J. Murch is an academic researcher from University of British Columbia. The author has contributed to research in topics: Somatic embryogenesis & Hypericum perforatum. The author has an hindex of 48, co-authored 165 publications receiving 8177 citations. Previous affiliations of Susan J. Murch include University of Guelph & National Tropical Botanical Garden.
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Diverse taxa of cyanobacteria produce β-N-methylamino-l-alanine, a neurotoxic amino acid
Paul Alan Cox,Sandra Anne Banack,Susan J. Murch,Ulla Rasmussen,Georgia Tien,Robert R. Bidigare,James S. Metcalf,Louise F. Morrison,Geoffrey A. Codd,Birgitta Bergman +9 more
TL;DR: It is reported here that a single neurotoxin, beta-N-methylamino-L-alanine, may be produced by all known groups of cyanobacteria, including cyanobacterial symbionts and free-living cyanob bacteria.
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Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam.
TL;DR: The biomagnification of BMAA through the Guam ecosystem fits a classic triangle of increasing concentrations of toxic compounds up the food chain, which may explain why the incidence of ALS-PDC among the Chamorro was 50-100 times the occurrence of amyotrophic lateral sclerosis elsewhere.
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Thidiazuron : A potent regulator of in vitro plant morphogenesis
TL;DR: Several reports indicate that TDZ may act through modulation of the endogenous plant growth regulators, either directly or as a result of induced stress, and several possibilities include the modification in cell membranes, energy levels, nutrient uptake, or nutrient assimilation.
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A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam
TL;DR: It is reported that BMAA occurs not only as a free amino acid in the Guam ecosystem but also can be released from a bound form by acid hydrolysis, which may explain the observed long latency period for neurological disease onset among the Chamorro people.
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Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam.
Susan J. Murch,Paul Alan Cox,Sandra Anne Banack,Sandra Anne Banack,John C. Steele,Oliver Sacks +5 more
TL;DR: Brain tissues of the Chamorro people of Guam who died of amyotrophic lateral sclerosis/Parkinsonism dimentia complex (ALS/PDC) are tested for the neurotoxin β‐methylamino‐l‐alanine (BMAA), which is produced by cyanobacteria and may be associated with some cases of neurodegenerative disease.