S
Susan J. Schroeder
Researcher at University of Oklahoma
Publications - 43
Citations - 3503
Susan J. Schroeder is an academic researcher from University of Oklahoma. The author has contributed to research in topics: RNA & Nucleic acid structure. The author has an hindex of 16, co-authored 41 publications receiving 3188 citations. Previous affiliations of Susan J. Schroeder include University of Rochester & State University of New York at Fredonia.
Papers
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Journal ArticleDOI
Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure
David H. Mathews,Matthew D. Disney,Jessica L. Childs,Susan J. Schroeder,Michael Zuker,Douglas H. Turner +5 more
TL;DR: A dynamic programming algorithm for prediction of RNA secondary structure has been revised to accommodate folding constraints determined by chemical modification and to include free energy increments for coaxial stacking of helices when they are either adjacent or separated by a single mismatch.
Journal ArticleDOI
Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson - Crick base pairs
Tianbing Xia,John SantaLucia,Mark E. Burkard,Ryszard Kierzek,Susan J. Schroeder,Xiaoqi Jiao,Christopher Cox,Douglas H. Turner +7 more
TL;DR: Improved thermodynamic parameters for prediction of RNA duplex formation are derived from optical melting studies of 90 oligoribonucleotide duplexes containing only Watson-Crick base pairs, and on average, the new parameters predict DeltaG degrees37, DeltaH degrees, DeltaS degrees, and TM within the limit of the model.
Journal ArticleDOI
Mutations outside the anisomycin-binding site can make ribosomes drug-resistant.
Gregor Blaha,Güliz Gürel,Susan J. Schroeder,Peter B. Moore,Thomas A. Steitz,Thomas A. Steitz +5 more
TL;DR: Eleven mutations that make Haloarcula marismortui resistant to anisomycin, an antibiotic that competes with the amino acid side chains of aminoacyl tRNAs for binding to the A-site cleft of the large ribosomal unit, have been identified in 23S rRNA.
Book ChapterDOI
Optical melting measurements of nucleic acid thermodynamics.
TL;DR: Optical melting experiments provide measurements of thermodynamic parameters for nucleic acids that are widely used in RNA structure prediction programs and DNA primer design software and practical details for instrument calibration, experimental design, and data interpretation are provided.
Journal ArticleDOI
Factors Affecting the Thermodynamic Stability of Small Asymmetric Internal Loops in RNA
TL;DR: Optical melting experiments were used to determine the thermodynamic parameters for oligoribonucleotides containing small asymmetric internal loops, which show a broad range of thermodynamic stabilities, which depend on loop size, asymmetry, sequence, closing base pairs, and length of helix stems.