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Susan LeJeune
Researcher at John Radcliffe Hospital
Publications - 4
Citations - 1916
Susan LeJeune is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Epidermal growth factor & Metastasis. The author has an hindex of 4, co-authored 4 publications receiving 1894 citations.
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Journal Article
Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis.
Micheie Relf,Susan LeJeune,Prudence A. E. Scott,Stephen B. Fox,Ken R. Smith,Russell Leek,Amir Moghaddam,R. M. Whitehouse,Roy Bicknell,Adrian L. Harris +9 more
TL;DR: Implications for therapy are that broad spectrum agents that block features common to these factors may be useful (e.g., antagonism of heparin-binding activity agents), because so many angiogenic factors are expressed.
Journal ArticleDOI
Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer.
Elizabeth Horak,N. Klenk,Russell Leek,Susan LeJeune,Kenneth G. C. Smith,N. Stuart,Adrian L. Harris,Michael Greenall,Kasia Stepniewska +8 more
TL;DR: The results suggest that angiogenesis is closely linked to metastasis, that it is acquired at a critical density of vessels, and that this process occurs as tumours enlarge or become more poorly differentiated.
Journal Article
Amphiregulin, Epidermal Growth Factor Receptor, and Estrogen Receptor Expression in Human Primary Breast Cancer
Susan LeJeune,Russell Leek,Elizabeth Horak,Gregory D. Plowman,Michael Greenall,Adrian L. Harris +5 more
TL;DR: The coexpression of epidermal growth factor receptor and amphiregulin in 35% of epidersmal growthFactor receptor positive cases raises the possibility of an autocrine loop in this subset of patients.
Journal Article
Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancer.
Elizabeth Horak,Kenneth G. C. Smith,L Bromley,Susan LeJeune,Michael Greenall,D Lane,Adrian L. Harris +6 more
TL;DR: In this paper, p53 expression was studied in 111 primary breast cancers with a monoclonal antibody (PAb240) that reacts with an epitope in mutant p53, and the association with EGFr expression suggests that these oncogenes interact in the pathogenesis of breast cancer.