Journal ArticleDOI
Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer.
Elizabeth Horak,N. Klenk,Russell Leek,Susan LeJeune,Kenneth G. C. Smith,N. Stuart,Adrian L. Harris,Michael Greenall,Kasia Stepniewska +8 more
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TLDR
The results suggest that angiogenesis is closely linked to metastasis, that it is acquired at a critical density of vessels, and that this process occurs as tumours enlarge or become more poorly differentiated.About:
This article is published in The Lancet.The article was published on 1992-11-07. It has received 847 citations till now. The article focuses on the topics: Platelet Endothelial Cell Adhesion Molecule & Angiogenesis.read more
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The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
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MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer.
Ping Ji,Sven Diederichs,Wenbing Wang,Sebastian Böing,Ralf Metzger,Paul M. Schneider,Nicola Tidow,Burkhard Brandt,Horst Buerger,Etmar Bulk,Michael Thomas,Wolfgang E. Berdel,Hubert Serve,Carsten Müller-Tidow +13 more
TL;DR: The identification of MALAT-1 emphasizes the potential role of noncoding RNAs in human cancer and contributes to the identification of early-stage NSCLC patients that are at high risk to develop metastasis.
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Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.
TL;DR: Assay of microvessel density within invasive tumors may prove valuable in selecting patients for aggressive adjuvant therapies in early prostate carcinoma, and was present predominantly in the poorly differentiated tumors.
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HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
TL;DR: It is demonstrated that HER2 signaling induced by overexpression in mouse 3T3 cells or heregulin stimulation of human MCF-7 breast cancer cells results in increased HIF-1α protein and VEGF mRNA expression that is dependent upon activity of PI3K, AKT, and the downstream kinase FRAP.
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Journal ArticleDOI
Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
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What is the evidence that tumors are angiogenesis dependent
TL;DR: Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.
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Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.
TL;DR: It is proposed that immunoprecipitation of p53 by PAb240 is diagnostic of mutation in both murine and human systems and suggested that the different point mutations which convert p53 from a recessive to a dominant oncogene exert a common conformational effect on the protein.
Journal Article
Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation.
TL;DR: It is suggested that dynamics of hematogenously initiated metastases depend strongly on the entry rate of tumor cell clumps into the circulation, which in turn is intimately linked to tumor vascularization.
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Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.
TL;DR: It is demonstrated that PECAM-1 mediates cell-cell adhesion and support the idea that it may be involved in some of the interactive events taking place during thrombosis, wound healing, and angiogenesis.