S
Susan M. Ludeman
Researcher at Albany College of Pharmacy and Health Sciences
Publications - 33
Citations - 1998
Susan M. Ludeman is an academic researcher from Albany College of Pharmacy and Health Sciences. The author has contributed to research in topics: Phosphoramide Mustard & Alkyltransferase. The author has an hindex of 18, co-authored 33 publications receiving 1904 citations. Previous affiliations of Susan M. Ludeman include University of Chicago & KAIST.
Papers
More filters
Journal ArticleDOI
Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy.
Michael P. Gamcsik,M. Daniel Clark,Susan M. Ludeman,James B. Springer,Michael A. D'Alessandro,Nicholas E. Simpson,Roxana Pourdeyhimi,C. Bryce Johnson,Stephanie D. Teeter,Stephen J. Blackband,Peter E. Thelwall +10 more
TL;DR: These studies demonstrate the utility of in vivo magnetic resonance for non-invasive monitoring of antioxidant uptake and metabolism in intact brain and evaluate the efficacy of various interventions for maintenance of brain glutathione.
Patent
A method of treating neuroblastoma
Susan M. Ludeman,Michael P. Gamcsik,Timothy A. Driscoll,James B. Springer,O. Michael Colvin,David J. Adams,Karel Base +6 more
TL;DR: In this article, a method of treating neuroblastoma tumors, including refractory ones, is described. But this method is not suitable for use in the treatment of neuroblastomas.
Journal ArticleDOI
Synthesis of 13C-labeled derivatives of cysteine for magnetic resonance imaging studies of drug uptake and conversion to glutathione in rat brain
Prince N. A. Amoyaw,James B. Springer,Michael P. Gamcsik,Rebecca L. Mutesi,Michael A. D'Alessandro,Collin R. Dempsey,Susan M. Ludeman +6 more
TL;DR: Three prodrugs of glutathione and cysteine were synthesized with a 13C-label such that in vivo uptake of each and conversion to glutathion in the brain could be monitored by magnetic resonance imaging.
Journal ArticleDOI
Synthesis of (3H, 33P)-phosphoramide and -isophosphoramide mustards and metabolites (3H)-chloroethylaziridine and -aziridine for studies of DNA alkylation
TL;DR: In this paper, the optimal times for in situ formation and storage of chloroethylaziridine and aziridine were determined for 3-H NMR experiments, and it was concluded that ∼ 13 h (5 half-lives) of reaction time would yield a solution of Aziridine which was relatively free of contaminants.
Patent
Method of activation of oxazaphosphorines
TL;DR: In this paper, a method for hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug) by administering the compound to the subject, and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxymate or oxidize the compound in the subject.