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Susan Marqusee
Researcher at University of California, Berkeley
Publications - 161
Citations - 10058
Susan Marqusee is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Protein folding & Protein structure. The author has an hindex of 49, co-authored 134 publications receiving 9243 citations. Previous affiliations of Susan Marqusee include University of California, San Francisco & California Institute for Quantitative Biosciences.
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Journal ArticleDOI
Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design
Susan Marqusee,Robert L. Baldwin +1 more
TL;DR: Four alanine-based peptides were designed, synthesized, and tested by circular dichroism for alpha-helix formation in H2O to test for helix stabilization by (Glu-, Lys+) ion pairs or salt bridges (H-bonded ion pairs).
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Unusually stable helix formation in short alanine-based peptides
TL;DR: Short, 16-residue, alanine-based peptides show stable alpha-helix formation in H2O, and the likely explanation for these results is that individualAlanine residues have a high helical potential.
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Direct Observation of the Three-State Folding of a Single Protein Molecule
TL;DR: Force-measuring optical tweezers were used to induce complete mechanical unfolding and refolding of individual Escherichia coli ribonuclease H (RNase H) molecules to map the energy landscape of RNase H.
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Relative helix-forming tendencies of nonpolar amino acids
TL;DR: It is concluded that the helix-forming tendency of a particular amino acid depends on the sequence context in which it occurs; and the restriction of side-chain rotamer conformations is important in determining the helIX-forming tendencies.
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Detection of rare partially folded molecules in equilibrium with the native conformation of RNaseH
TL;DR: Data suggest that the first region to fold is the thermodynamically most stable portion of the protein and that the molten globule is a high free energy conformation present at equilibrium in the native state.