E
Elizabeth A. Shank
Researcher at University of North Carolina at Chapel Hill
Publications - 40
Citations - 2445
Elizabeth A. Shank is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Bacillus subtilis & Biofilm. The author has an hindex of 19, co-authored 35 publications receiving 2052 citations. Previous affiliations of Elizabeth A. Shank include Harvard University & University of Massachusetts Medical School.
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Journal ArticleDOI
Direct Observation of the Three-State Folding of a Single Protein Molecule
TL;DR: Force-measuring optical tweezers were used to induce complete mechanical unfolding and refolding of individual Escherichia coli ribonuclease H (RNase H) molecules to map the energy landscape of RNase H.
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The folding cooperativity of a protein is controlled by its chain topology
TL;DR: It is speculated that proteins may have evolved to select certain topologies that increase coupling between regions to avoid areas of the landscape that lead to kinetic trapping and misfolding.
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MS/MS networking guided analysis of molecule and gene cluster families
Don D. Nguyen,Cheng-Hsuan Wu,Wilna J. Moree,Anne Lamsa,Marnix H. Medema,X. Zhao,Ronnie G. Gavilan,Marystella Aparicio,Librada A. Atencio,Chanaye Jackson,Javier Ballesteros,Joel Sanchez,Jeramie D. Watrous,Vanessa V. Phelan,Corine van de Wiel,Roland D. Kersten,Samina Mehnaz,René De Mot,Elizabeth A. Shank,Pep Charusanti,Harish Nagarajan,Brendan M. Duggan,Bradley S. Moore,Nuno Bandeira,Bernhard O. Palsson,Kit Pogliano,Marcelino Gutiérrez,Pieter C. Dorrestein +27 more
TL;DR: This paper matched the molecular families of peptide natural products produced by 42 bacilli and 18 pseudomonads through the generation of amino acid sequence tags from MS/MS data of specific clusters found in the MS/ MS network, providing the ability to link particular molecules with the genes that produced them.
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New developments in microbial interspecies signaling.
TL;DR: This review will focus on how bacterial small molecules modulate these interspecies interactions, particularly complex relationships such as those between microbes and insects, interactions resulting in non-antagonistic outcomes (i.e. developmental and morphological processes), and how co-culture can lead to the discovery of new small molecules.
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Design of synthetic bacterial communities for predictable plant phenotypes.
Sur Herrera Paredes,Tianxiang Gao,Theresa F. Law,Omri M. Finkel,Tatiana S. Mucyn,Paulo José Pereira Lima Teixeira,Isai Salas González,Meghan E. Feltcher,Matthew J. Powers,Elizabeth A. Shank,Corbin D. Jones,Vladimir Jojic,Jeffery L. Dangl,Gabriel Castrillo +13 more
TL;DR: It is demonstrated that plant–bacterium binary-association assays inform the design of small synthetic communities with predictable phenotypes in the host and that it is possible to infer causal relationships between microbiota membership and host phenotypes and to use these inferences to rationally design novel communities.