Susanne Saurer

TL;DR: Wyllie et al. as discussed by the authors showed that post-lactational mammary gland involution results in a dramatic drop in ODC, a gene involved in synthesis of a component of milk, and nearly simultaneous induction of SGP-2, associated with apoptotic cell death.

TL;DR: Three genes isolated in the laboratory because of their association with apoptotic processes in the ovary, mammary gland, and prostate served as the focus of the investigation, and seem promising candidates-by virtue of their specific expression in distinct tissues undergoing programmed cell death-as mediators of stimuli leading to apoptosis and subsequent phagocytosis.

TL;DR: The differential display method has been used in the laboratory as a coincidence analysis to isolate genes expressed in common in each of three different rat tissues undergoing physiological apoptosis, showing a clear association with apoptosis.

TL;DR: In this paper, the authors compared the expression of the tissue-remodeling enzymes stromelysin-l, a matrix metalloproteinase, and its inhibitor, tissue inhibitor of METALOProteinase-l (TIMP-l), during mammary gland involution and carcinogenesis in mouse.

TL;DR: A role for DDC-4/sFRP-4 in abrogating an epithelial cell survival pathway at the onset of mammary gland involution is shown.