Showing papers by "Susumu Kobayashi published in 1979"
TL;DR: An efficient synthesis of a variety of N -substituted or N -unsubtituted amidinoformic acids was developed starting with benzyl cyanoformate as discussed by the authors.
17 citations
TL;DR: In this article, an antiviral nucleoside or virazole was synthesized efficiently and regioselectively starting with benzyl cyanoformate, which was then used to synthesize an antimalarial drug.
14 citations
TL;DR: In this paper, a new methodology which leads to α,β-unsaturated α-amino acids has been developed through a carbon-carbon forming reaction using ethyl cyanoformate and active methylene compounds in the presence of zinc chloride and triethyl amine.
11 citations
Patent•
29 May 1979
TL;DR: In this article, a 3-substituted-1,2,4-triazole and an OH-protected D-ribose with ammonia was used to prepare virazole useful as an antiviral agent.
Abstract: PURPOSE: To prepare virazole useful as an antiviral agent effective to a wide varieties of viruses, by reacting the condensation product of a 3-substituted-1,2,4-triazole and an OH-protected D-ribose with ammonia. CONSTITUTION: The virazole of formula IV is prepared by condensing a 3-substituted-1,2,4-triazole of formula II (R' is aralkyl) with an OH-protected D-ribose of formula II (R is acyl) to obtian an 1-substituted ribofuranosyl-3-aralkyloxycarbonyl- 1,2,4-triazole of formula III, and then reacting the product with ammonia. The condensation of the compounds of formulas I and II is carried out by heating and melting the compounds in the presence of a Lewis acid (e.g. bis(D-nitrophenyl) phosphate] as a catalyst. The reaction with ammonia is pref. carried out under cooling or at room temperature to attain the complete position-selectiveness of the compound of formula IV. COPYRIGHT: (C)1980,JPO&Japio
2 citations