Suzanne Campion

TL;DR: Both central and peripheral inflammation can exacerbate local brain inflammation and neuronal death, and the finding that a single acute systemic inflammatory event can induce neuronal death in the CNS has implications for therapy in neurodegenerative diseases.

TL;DR: It is demonstrated that transient systemic inflammation superimposed on neurodegenerative disease acutely exacerbates cognitive and motor symptoms of disease and accelerates disease progression.

TL;DR: Clear CNS effects of peripheral TLR3 stimulation are demonstrated and will be useful in studying aspects of the effects of systemic viral infection on brain function in both normal and pathological situations.

TL;DR: Analysis of peripheral blood mononuclear cells and intestinal tissues from patients with inflammatory bowel diseases vs controls found that reactivity to intestinal bacteria is a normal property of the human CD4+ T-cell repertoire, and does not necessarily indicate disrupted interactions between immune cells and the commensal microbiota.

TL;DR: It is hypothesized that systemic challenge with poly I:C, during chronic neurodegenerative disease, would amplify CNS inflammation and exacerbate disease, and indicates that type I interferon responses in the brain merit further study.