S
Svetoslav Dimitrov
Researcher at Temple University
Publications - 6
Citations - 130
Svetoslav Dimitrov is an academic researcher from Temple University. The author has contributed to research in topics: Angiogenesis & Binding site. The author has an hindex of 5, co-authored 5 publications receiving 128 citations.
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Journal ArticleDOI
Integrin α2β1 mediates the anti-angiogenic and anti-tumor activities of angiocidin, a novel tumor-associated protein
Yamini Sabherwal,Vicki L. Rothman,Svetoslav Dimitrov,Darryl Z. L'Heureux,Cezary Marcinkiewicz,Mahesh C. Sharma,George P. Tuszynski +6 more
TL;DR: It is reported that angiocidin may inhibit angiogenesis by binding collagen and its receptors and this results provide support for the concept that targeting matrix–cell interactions is a viable strategy for the development of anti-cancer therapeutics.
Journal ArticleDOI
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin‐1
Jing Zhou,Vicki L. Rothman,Irene Sargiannidou,Svetoslav Dimitrov,Cuie Qiu,Elana Smith,Joel B. Sheffield,Mahesh C. Sharma,George P. Tuszynski +8 more
TL;DR: The results suggest that the anti‐tumor activity of TSP‐1 reported in many studies may be mediated in part by binding proteins such as angiocidin, which may function as tumor‐suppressor proteins, which limit the growth of tumors by inhibiting angiogenesis and cell matrix interaction.
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The Novel Angiogenic Inhibitor, Angiocidin, Induces Differentiation of Monocytes to Macrophages
TL;DR: It is shown that angiocidin activates monocytes to secrete cytokines and differentiates them to a macrophage-like phenotype through at least two pathways mediated by MAPK and NF-kappaB, as well as PI3K.
Journal ArticleDOI
Angiocidin promotes pro-inflammatory cytokine production and antigen presentation in multiple sclerosis
Sergey G. Kremlev,Anita L. Gaurnier-Hausser,Luis Del Valle,Georgina Perez-Liz,Svetoslav Dimitrov,George P. Tuszynski +5 more
TL;DR: It is demonstrated that angiocidin and interleukin-7 (IL-7) are over-expressed in brain lesions of MS patients and markedly stimulates STAT3 expression in these cell populations.
Journal ArticleDOI
Endothelial apoptotic activity of angiocidin is dependent on its polyubiquitin binding activity.
Svetoslav Dimitrov,Yamini Sabherwal,D D Raymond,Darryl Z. L'Heureux,Qun Lu,Qun Lu,George P. Tuszynski +6 more
TL;DR: It is shown that angiocidin binds polyubiquitin in vivo with high affinity and colocalises with ubiquitinated proteins on the surface of endothelial cells.