S
Sviatlana Zhyzhneuskaya
Researcher at Newcastle University
Publications - 16
Citations - 2121
Sviatlana Zhyzhneuskaya is an academic researcher from Newcastle University. The author has contributed to research in topics: Weight loss & Type 2 diabetes. The author has an hindex of 8, co-authored 15 publications receiving 1272 citations.
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Journal ArticleDOI
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Renae J. Stefanetti,Michael I. Trenell,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Naveed Sattar,Roy Taylor +24 more
TL;DR: The findings show that, at 12 months, almost half of participants achieved remission to a non-diabetic state and off antidiabetic medications, from baseline to 12 months.
Journal ArticleDOI
Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Claudia-Martina Messow,Naveed Sattar,Roy Taylor +23 more
TL;DR: Sustained remission was linked to the extent of sustained weight loss, and the DiRECT programme sustained remissions at 24 months for more than a third of people with type 2 diabetes.
Journal ArticleDOI
Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery.
Roy Taylor,Ahmad Al-Mrabeh,Sviatlana Zhyzhneuskaya,Carl Peters,Alison C. Barnes,Benjamin S. Aribisala,Kieren G. Hollingsworth,John C. Mathers,Naveed Sattar,Michael E. J. Lean +9 more
TL;DR: This study demonstrates that β cell ability to recover long-term function persists after diagnosis, changing the previous paradigm of irreversible loss of β cell function in type 2 diabetes.
Journal ArticleDOI
Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss
Ahmad Al-Mrabeh,Sviatlana Zhyzhneuskaya,Carl Peters,Alison C. Barnes,Shaden Melhem,Aaron Jesuthasan,Benjamin S. Aribisala,Kieren G. Hollingsworth,Georg Lietz,John C. Mathers,Naveed Sattar,Michael E. J. Lean,Roy Taylor +12 more
TL;DR: Timely relationships between VLDL1-triglyceride production, hepatic palmitic acid flux, intra-pancreatic fat, and β-cell function are observed to drive development and reversal of type 2 diabetes.
Journal ArticleDOI
The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial.
Wilma S Leslie,Ian Ford,Naveed Sattar,Kieren G. Hollingsworth,Ashley J. Adamson,Falko F. Sniehotta,Louise McCombie,Naomi Brosnahan,H. M. Ross,John C. Mathers,Carl Peters,George Thom,Alison C. Barnes,Sharon Kean,Yvonne McIlvenna,Angela M. Rodrigues,Lucia Rehackova,Sviatlana Zhyzhneuskaya,Roy Taylor,Michael E. J. Lean +19 more
TL;DR: The Diabetes Remission Clinical Trial (DiRECT) was designed to determine whether a structured, intensive, weight management programme, delivered in a routine Primary Care setting, is a viable treatment for achieving durable normoglycaemia.