Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery.
Roy Taylor,Ahmad Al-Mrabeh,Sviatlana Zhyzhneuskaya,Carl Peters,Alison C. Barnes,Benjamin S. Aribisala,Kieren G. Hollingsworth,John C. Mathers,Naveed Sattar,Michael E. J. Lean +9 more
TLDR
This study demonstrates that β cell ability to recover long-term function persists after diagnosis, changing the previous paradigm of irreversible loss of β cell function in type 2 diabetes.About:
This article is published in Cell Metabolism.The article was published on 2018-10-02 and is currently open access. It has received 236 citations till now. The article focuses on the topics: Type 2 diabetes & Diabetes mellitus.read more
Citations
More filters
Journal ArticleDOI
The integrative biology of type 2 diabetes.
Michael Roden,Gerald I. Shulman +1 more
TL;DR: Recent studies providing insights into insulin resistance and increased hepatic gluconeogenesis associated with obesity and type 2 diabetes are summarized, focusing on data from humans and relevant animal models.
Journal ArticleDOI
Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Claudia-Martina Messow,Naveed Sattar,Roy Taylor +23 more
TL;DR: Sustained remission was linked to the extent of sustained weight loss, and the DiRECT programme sustained remissions at 24 months for more than a third of people with type 2 diabetes.
Journal ArticleDOI
Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship.
Jakub Mesinovic,Ayse Zengin,Barbora de Courten,Peter R. Ebeling,Peter R. Ebeling,David Scott,David Scott +6 more
TL;DR: The current literature highlighting the bidirectional relationship between T2DM and sarcopenia is discussed, current research gaps and treatments are highlighted, and recommendations for future research are provided.
Journal ArticleDOI
From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options
Amalia Gastaldelli,Kenneth Cusi +1 more
TL;DR: The altered pathophysiological mechanisms that underlie the development of type 2 diabetes in NAFLD and vice versa are discussed and pharmacological agents currently available to treat T2D that could potentially be useful for the management of NASH are discussed.
References
More filters
Journal ArticleDOI
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
Kerry L. Donnelly,Coleman Smith,Sarah Jane Schwarzenberg,Jose Jessurun,Mark D. Boldt,Elizabeth J. Parks +5 more
TL;DR: In this article, the authors quantified the biological sources of hepatic and plasma lipoprotein TAG in NAFLD patients, using stable isotopes for four days to label and track serum nonesterified fatty acids (NEFAs), dietary fatty acids, and those derived from the de novo lipogenesis (DNL) pathway, present in liver tissue and lipid TAG.
Journal ArticleDOI
Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.
TL;DR: The proportion of patients who maintained target glycemic levels declined markedly over 9 years of follow-up, and the progressive deterioration of diabetes control was such that after 3 years approximately 50% of patients could attain this goal with monotherapy, and by 9 years this declined to approximately 25%.
Journal ArticleDOI
Calculation of substrate oxidation rates in vivo from gaseous exchange
TL;DR: It is shown that erroneous results are obtained in the presence of metabolic processes such as lipogenesis and gluconeogenesis, so that the apparently negative rates encountered in patients infused with glucose do quantitatively represent net rates of synthesis.
Journal ArticleDOI
Banting Lecture 2001: Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes
TL;DR: The primary focus of this lecture will be on the first of these issues, which is the pathophysiological basis for type 2 diabetes and why is their rate of appearance accelerating so rapidly at this particular juncture of human history.
Journal ArticleDOI
Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012
TL;DR: The recent prevalence and update US trends in total diabetes, diagnosed diabetes, and undiagnosed diabetes using National Health and Nutrition Examination Survey (NHANES) data was estimated using cross-sectional surveys conducted between 1988-1994 and 1999-2012.
Related Papers (5)
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Renae J. Stefanetti,Michael I. Trenell,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Naveed Sattar,Roy Taylor +24 more
Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Claudia-Martina Messow,Naveed Sattar,Roy Taylor +23 more