J
John C. Mathers
Researcher at Newcastle University
Publications - 597
Citations - 28579
John C. Mathers is an academic researcher from Newcastle University. The author has contributed to research in topics: DNA methylation & Medicine. The author has an hindex of 82, co-authored 545 publications receiving 23776 citations. Previous affiliations of John C. Mathers include University of Newcastle & University of Dundee.
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Journal ArticleDOI
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Renae J. Stefanetti,Michael I. Trenell,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Naveed Sattar,Roy Taylor +24 more
TL;DR: The findings show that, at 12 months, almost half of participants achieved remission to a non-diabetic state and off antidiabetic medications, from baseline to 12 months.
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Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
E. L. Lim,Kieren G. Hollingsworth,Benjamin S. Aribisala,M J. Chen,John C. Mathers,Roy Taylor +5 more
TL;DR: Normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone, and was associated with decreased pancreatic and liver triacylglycerol stores.
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Tracking of obesity-related behaviours from childhood to adulthood: A systematic review
TL;DR: Evidence of tracking of both physical activity and of diet between childhood and adulthood with estimates of strength of tracking in a similar order is found, which may give greater impetus to the development of interventions aimed to prevent the persistence of obesity from childhood into adulthood.
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Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
John Burn,Anne-Marie Gerdes,Finlay A. Macrae,Jukka-Pekka Mecklin,Gabriela Moeslein,Sylviane Olschwang,D. Eccles,D. Gareth Evans,Eamonn R. Maher,Lucio Bertario,Marie Luise Bisgaard,Malcolm G. Dunlop,Judy W. C. Ho,Shirley V. Hodgson,Annika Lindblom,Jan Lubinski,Patrick J. Morrison,Victoria Murday,Raj Ramesar,Lucy Side,Rodney J. Scott,Huw Thomas,Hans F. A. Vasen,Gail Barker,Gillian Crawford,Faye Elliott,Mohammad Movahedi,Kirsi Pylvänäinen,Juul T. Wijnen,Riccardo Fodde,Henry T. Lynch,John C. Mathers,D. Timothy Bishop +32 more
TL;DR: The CAPP2 trial aimed to investigate the antineoplastic effects of aspirin and a resistant starch in carriers of Lynch syndrome, the major form of hereditary colorectal cancer, and long-term follow-up of participants randomly assigned to aspirin or placebo is reported.
Journal ArticleDOI
Origins of lifetime health around the time of conception: causes and consequences.
Tom P. Fleming,Adam J. Watkins,Miguel A. Velazquez,John C. Mathers,Andrew M. Prentice,Judith Stephenson,Mary Barker,Mary Barker,Richard Saffery,Chittaranjan S. Yajnik,Judith J. Eckert,Mark A. Hanson,Mark A. Hanson,Terrence Forrester,Peter D. Gluckman,Peter D. Gluckman,Keith M. Godfrey,Keith M. Godfrey +17 more
TL;DR: It is proposed that the evidence for periconceptional effects on lifetime health is now so compelling that it calls for new guidance on parental preparation for pregnancy, beginning before conception, to protect the health of offspring.