S
Sylvain Cottens
Researcher at Novartis
Publications - 43
Citations - 3133
Sylvain Cottens is an academic researcher from Novartis. The author has contributed to research in topics: Protein kinase C & Transplantation. The author has an hindex of 18, co-authored 41 publications receiving 3033 citations.
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Journal ArticleDOI
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.
Gabriele Weitz-Schmidt,Karl Welzenbach,Volker Brinkmann,Tetsji Kamata,Joerg Kallen,Christian Bruns,Sylvain Cottens,Yoshikazu Takada,Ulrich Hommel +8 more
TL;DR: Targeting of the statin-binding site of LFA-1 could be used to treat diseases such as psoriasis, rheumatoid arthritis, ischemia/reperfusion injury and transplant rejection.
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SDZ RAD, A NEW RAPAMYCIN DERIVATIVE: Pharmacological Properties In Vitro and In Vivo
Walter Schuler,Richard Sedrani,Sylvain Cottens,B Häberlin,M Schulz,Henk-Jan Schuurman,Gerhard Zenke,Hans-Guenter Zerwes,Max H. Schreier +8 more
TL;DR: SDZ RAD is a new, orally active rapamycin-derivative that is immunosuppressive in vitro that efficiently prevents graft rejection in rat models of allotransplantation and has been selected for development for use in combination with cyclosporine A to prevent acute and chronic rejection after solid organ allotransplplantation.
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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.
Jörg Kallen,Karl Welzenbach,Paul Ramage,Dieter Geyl,Richard W. Kriwacki,Glen B. Legge,Sylvain Cottens,Gabriele Weitz-Schmidt,Ulrich Hommel +8 more
TL;DR: L lovastatin, a drug clinically used for lowering cholesterol levels, inhibits the interaction of human LFA-1 with its counter-receptor intercellular adhesion molecule-1, and the first three-dimensional structure of an integrin inhibitor bound to its receptor is revealed.
Journal ArticleDOI
SDZ RAD, a new rapamycin derivative: synergism with cyclosporine.
Henk-Jan Schuurman,Sylvain Cottens,Serge Fuchs,Joanne Joergensen,Timo Meerloo,Richard Sedrani,Madeleine Tanner,Gerhard Zenke,Walter Schuler +8 more
TL;DR: Isobologram analysis of checkerboard titrations of SDZ RAD and cyclosporine in two-way mouse mixed lymphocyte reactions indicates a synergistic interaction in vitro, and they form a promising synergistic drug combination in allotransplantation.