Men at risk: occupation and male infertility☆

https://apps.who.int/iris/bitstream/10665/78102/1/WHO_HSE_PHE_IHE_2013.1_eng.pdf

State of the Science of Endocrine Disrupting Chemicals - 2012

It is predicted that Japan and European Union will soon experience appreciable decreases in their populations due to persistently low total fertility rates (TFR) below replacement level (2.1 child ...

https://www.physiology.org/doi/pdf/10.1152/physrev.00017.2015

Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility

http://ruby.fgcu.edu/Courses/ndemers/Current%20topics%20endocrine/15%20yrs%20afterWingspread%20EDCs2008.pdf

Fifteen Years after Wingspread -Environmental Endocrine Disrupters and Human and Wildlife Health : Where We are Today and Where We Need to Go

Evidence that mammalian sex ratios at birth are partially controlled by parental hormone levels at the time of conception.

In mid-1977 a number of cases of infertility among male pesticide workers in California came to light. A description of this problem was published as a Preliminary Communication in The Lancet. A larger clinical-epidemiological study was undertaken to better understand the exposure-effect relationships involved. Of 142 non-vasectomized men providing semen samples, 107 had been exposed to 1,2-dibromo-3-chloropropane (DBCP) and 35 had not been exposed. There was a clearcut difference in both the distribution of sperm counts and the median counts between the exposed men and the not-exposed men, Of the exposed, 13.1% were azoospermic, 16.8% were severely oligospermic, and 15.8% were mildly oligospermic. Among the controls, 2.9% were azoospermic, none were severely oligospermic, and 5.7% were mildly oligospermic. Under workplace conditions, DBCP appears to have a selective effect on the seminiferous tubules.

T H Milby

Papers

Testicular function in DBCP exposed pesticide workers.