T
T Rzymski
Researcher at John Radcliffe Hospital
Publications - 3
Citations - 429
T Rzymski is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Unfolded protein response & ATF4. The author has an hindex of 3, co-authored 3 publications receiving 383 citations.
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Journal ArticleDOI
Regulation of autophagy by ATF4 in response to severe hypoxia.
T Rzymski,Manuela Milani,Luke R.G. Pike,Francesca M. Buffa,Howard R. Mellor,Laura Winchester,Isabel M. Pires,Ester M. Hammond,I Ragoussis,Adrian L. Harris +9 more
TL;DR: It is demonstrated that severe hypoxia leads to ER stress and induces ATF4-dependent autophagy through LC3 as a survival mechanism, and small interfering RNA and microarray analysis is used to provide the first whole-genome analysis of genes regulated by ATF4 in cancer cells in response to severe and prolonged hypoxic stress.
Journal ArticleDOI
An oncogenic role of eIF3e/INT6 in human breast cancer
M Grzmil,T Rzymski,Manuela Milani,Adrian L. Harris,Richard G. Capper,Nigel J. Saunders,Anita Salhan,Jiannis Ragoussis,Chris J. Norbury +8 more
TL;DR: The study data suggest that eIF3e has a positive role in breast cancer progression, and regulates the translation, and in some cases abundance, of mRNAs involved in key aspects of cancer cell biology.
Journal ArticleDOI
Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4.
TL;DR: The response to anoxia is mediated by three pathways independently of HIF, suggesting that combined therapeutic approaches would be needed to maximize effects against this pathway.