Taekwon Son

TL;DR: It is demonstrated that CDK12 promotes tumor initiation as a novel regulator of cancer stem cells (CSCs) and induces anti-HER2 therapy resistance in human breast cancer and kinase activity inhibition facilitates anticancer efficacy of trastuzumab in HER2+ tumors.

TL;DR: Investigating the molecular features underlying senescence and rejuvenation during aged cell reprogramming and identified novel factors that can overcome age‐associated barriers demonstrate that maintenance of mitochondrial NAD+ levels is critical for reversing the mechanisms of aging and ensuring that cells collected from aged individuals are of high quality.

TL;DR: RBP2 activates ER-IGF1R-ErbB signaling cascade in multiple ways to induce tamoxifen resistance, suggesting that RBP2 is a potential therapeutic target for ER-driven cancer.

TL;DR: It is reported that N SD3-induced methylation of H3K36 is crucial for breast tumor initiation and metastasis, suggesting NSD3 as an actionable therapeutic target in metastatic breast cancer.

TL;DR: Findings indicate that HK2-CGI N-shore hypomethylation and HK2 -CGI hypermethylation affect HK2 expression by influencing the interaction between HIF 1α and HRE.