Asymmetric enamine catalysis.

Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals.

Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well-established and powerful synthetic tool for the chemo- and enantioselective functionalization of carbonyl compounds. In the last eight years alone, this field has grown at such an extraordinary pace that it is now recognized as an independent area of synthetic chemistry, where the goal is the preparation of any chiral molecule in an efficient, rapid, and stereoselective manner. This has been made possible by the impressive level of scientific competition and high quality research generated in this area. This Review describes this "Asymmetric Aminocatalysis Gold Rush" and charts the milestones in its development. As in all areas of science, progress depends on human effort.

Asymmetric aminocatalysis--gold rush in organic chemistry.

Proline-catalyzed asymmetric reactions

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

l-Proline rubidium salt catalyzes the asymmetric Michael addition of malonate anions to prochiral enones and enals. This method can be applied to a wide range of substrates to give adducts with a p...

Asymmetric michael addition of malonate anions to prochiral acceptors catalyzed by l-proline rubidium salt

A Catalytic Enantioselective Michael Addition of a Simple Malonate to Prochiral α,β‐Unsaturated Ketoses and Aldehydes

Asymmetric Michael addition of nitroalkanes to prochiral acceptors catalyzed by proline rubidium salts

Catalytic asymmetric michael addition of nitroalkane to enone and enal

Eine katalytische enantioselektive Michael-Addition eines Malonats an prochirale α,β-ungesättigte Aldehyde und Ketone†

Tai Shiraishi

Papers

Asymmetric michael addition of malonate anions to prochiral acceptors catalyzed by l-proline rubidium salt

A Catalytic Enantioselective Michael Addition of a Simple Malonate to Prochiral α,β‐Unsaturated Ketoses and Aldehydes

Asymmetric Michael addition of nitroalkanes to prochiral acceptors catalyzed by proline rubidium salts

Catalytic asymmetric michael addition of nitroalkane to enone and enal

Eine katalytische enantioselektive Michael-Addition eines Malonats an prochirale α,β-ungesättigte Aldehyde und Ketone†