T
Taisuke Ohnoshi
Publications - 3
Citations - 156
Taisuke Ohnoshi is an academic researcher. The author has contributed to research in topics: Drug resistance & Clonogenic assay. The author has an hindex of 3, co-authored 3 publications receiving 155 citations.
Papers
More filters
Journal Article
Establishment of Methotrexate-resistant Human Acute Lymphoblastic Leukemia Cells in Culture and Effects of Folate Antagonists
Taisuke Ohnoshi,Takao Ohnuma,Isao Takahashi,Kevin J. Scanlon,Barton A. Kamen,James F. Holland +5 more
TL;DR: Data suggest that either the number of folate transport sites or the turnover rate of these sites has been reduced in the MTX-resistant cell line, which might prove to be unique in treating patients with acute lymphoblastic leukemia when the leukemic cells develop transport resistance to MTX.
Journal Article
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.
Takao Ohnuma,Ruju Julia Lo,Kevin J. Scanlon,Barton A. Kamen,Taisuke Ohnoshi,Sandra R. Wolman,James F. Holland +6 more
TL;DR: A human acute lymphoblastic T-cell line, MOLT-3, was fed with Roswell Park Memorial Institute Medium 1640 supplemented with 10% fetal bovine serum and antibiotics which contained increasing concentrations of methotrexate (MTX).
Journal ArticleDOI
Combined Cytotoxicity Effect of Hyperthermia and Anthracycline Antibiotics on Human Tumor Cells
TL;DR: The data indicate that human tumor cell lines have a substantial variety in heat sensitivity and that not every anthracycline antitumor agent is potentiated by temperature, and that ACM's thermoresponse is unique among anthrACYcline antibiotics studied.