T
Takako Koujin
Researcher at National Institute of Information and Communications Technology
Publications - 39
Citations - 2138
Takako Koujin is an academic researcher from National Institute of Information and Communications Technology. The author has contributed to research in topics: Barrier-to-autointegration factor & Emerin. The author has an hindex of 18, co-authored 38 publications receiving 1886 citations.
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Journal ArticleDOI
Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF.
Kenneth K. Lee,Tokuko Haraguchi,Richard S. Lee,Takako Koujin,Yasushi Hiraoka,Katherine L. Wilson +5 more
TL;DR: The demonstration that emerin binds directly to barrier-to-autointegration factor (BAF), a DNA-bridging protein, provides proof in principle that all LEM-domain nuclear proteins can interact with BAF, with interesting implications for chromatin attachment to the nuclear envelope.
Journal ArticleDOI
BAF is required for emerin assembly into the reforming nuclear envelope.
Tokuko Haraguchi,Takako Koujin,Miriam Segura-Totten,Kenneth K. Lee,Yosuke Matsuoka,Yoshihiro Yoneda,Katherine L. Wilson,Yasushi Hiraoka +7 more
TL;DR: It is concluded that BAF is required for the assembly of emerin and A-type lamins at the reforming NE during telophase, and may mediate their stability in the subsequent interphase.
Journal ArticleDOI
Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly
Tokuko Haraguchi,Tokuko Haraguchi,Tomoko Kojidani,Takako Koujin,Takeshi Shimi,Hiroko Osakada,Chie Mori,Akitsugu Yamamoto,Yasushi Hiraoka,Yasushi Hiraoka +9 more
TL;DR: Time-lapse, FRAP and FRET analyses in human cells suggest that the MT-mediated BAF accumulation at the core facilitates NE assembly at the end of mitosis.
Journal ArticleDOI
Live fluorescence imaging reveals early recruitment of emerin, LBR, RanBP2, and Nup153 to reforming functional nuclear envelopes
Tokuko Haraguchi,Takako Koujin,Tomohiro Hayakawa,Toru Kaneda,Chihiro Tsutsumi,Naoko Imamoto,Chihiro Akazawa,Jun Sukegawa,Yoshihiro Yoneda,Yasushi Hiraoka +9 more
TL;DR: Results showed that emerin, LBR, and several NPC components, but not Tpr, reconstitute around chromosomes very early in telophase prior to the recovery of nuclear import activity.
Journal ArticleDOI
Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy.
Tokuko Haraguchi,James M. Holaska,Miho Yamane,Takako Koujin,Noriyo Hashiguchi,Chie Mori,Katherine L. Wilson,Yasushi Hiraoka +7 more
TL;DR: The results suggest that Btf localization is regulated by apoptotic signals, and that loss of emerin binding to Btf may be relevant to muscle wasting in Emery-Dreifuss muscular dystrophy.