Modelling reactive distillation

Survey Generic properties and control of linear structured systems: a survey

Computer Solution of Linear Algebraic Systems. By G. Forsythe and C. B. Moler. Pp. xi, 148. 1967. (Prentice-Hall.)

A culture of sulfate reducing bacteria (SRB) growing on lactate and sulfate was incubated at different pH values in the range of 5.8-7.0. The effect of pH on growth rate was determined in this pH range; the highest growth rate was observed at pH 6.7. Hydrogen sulfide produced from sulfate reduction was found to have a direct and reversible toxicity effect on the SRB. A hydrogen sulfide Concentration of 547 mg/L (16.1 mM) completely inhibited the culture growth. Comparison between acetic acid and hydrogen sulfide inhibition is presented and the concomitant inhibition kinetics are mathematically described.

Effect of hydrogen sulfide on growth of sulfate reducing bacteria.

The synthesis of cost optimal heat exchanger networks. An industrial review of the state of the art

This work is concerned with the optimization study of the semibatch fermentation by which an amino acid is produced. The particular fermentation studied is the synthesis of lysine by the auxotrophic mutant. Applying Green's theorem to the maximization problem was proposed, and it succeeded in determining the feed rate of the substrate that maximized the production rate of the desired product.

Optimal control of a semibatch fermentation

Molecular weight distribution control in a batch polymerization reactor

The objective of this article is to propose an algorithm for the on-line estimation of the specific growth rate in a batch or a fed-batch fermentation process. The algorithm shows the practical procedure for the estimation method utilizing the macroscopic balance and the extended Kalman filter. A number of studies of the on line estimation have been presented. However, there are few studies discussing about the selection of the observed variables and for the tuning of some parameters of the extended Kalman filter, such as covariance matrix and initial values of the state.

The beginning of this article is devoted to explain the selection of the observed variable. This information is very important in terms of the practical know-how for using technique. It is discovered that the condition number is a practically useful and valid criterion for number is a practically useful and valid criterion for choosing the variable to be observed.

Next, when the extended Kalman filter in applied to the online estimation of the specific growth rate, which is directly unmeasurable, criteria for judging the validity of the estimated value from the observed data are proposed. Based on the proposed criterial, the system equation of the specific growth rate is selected and initial value of the state variable and covariance matrix of the system noises are adjusted. From many experiments, it is certified that the specific growth rate in the batch or fed -batch fermentation can be estimated accurately by means of the algorithm proposed here. In these experiments, that is, when the cell concentration is measured directly, the extended Kalman filter using the convariance matrix with a constant element can estimate more accurately values of the specific growth rate than the adaptive extended Kalman filter does.

An algorithmic approach to constructing the on-line estimation system for the specific growth rate.

A feedback control system of the glucose feed rate in a bakers' yeast fed-batch culture was developed by keeping the ethanol concentration constant A PID controller and on–off controller were applied and discussed with the aid of the porous Teflon tubing method Experimental results showed the effectiveness of the control system for avoiding the glucose effect and glucose starvation It was shown that the feedback control system developed hare could achieve a maximum specific growth rate of 03 h−1 or a maximum cell yield of 05 g cell/g glucose in the fedhyphen;batch culture

Takeichiro Takamatsu

Papers

Optimal control of a semibatch fermentation

Molecular weight distribution control in a batch polymerization reactor

An algorithmic approach to constructing the on-line estimation system for the specific growth rate.

Maximum production in a bakers' yeast fed‐batch culture by a tubing method

Paper: A geometric approach to multivariable control system design of a distillation column