T
Takeki Tsutsui
Researcher at The Nippon Dental University
Publications - 84
Citations - 2100
Takeki Tsutsui is an academic researcher from The Nippon Dental University. The author has contributed to research in topics: Hamster & Gene mutation. The author has an hindex of 25, co-authored 84 publications receiving 2017 citations. Previous affiliations of Takeki Tsutsui include National Institutes of Health.
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Journal Article
Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosomal mechanism in carcinogenesis.
TL;DR: It is suggested that DES induces chromosome nondisjunction, and possible mechanisms for DES-induced aneuploidy and the evidence supporting a role for nonrandom numerical chromosome changes in neoplastic development, as well as significance of aneuPLoidy in cancer, are discussed.
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Benzene-, catechol-, hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells.
TL;DR: Evidence is provided that benzene and several of its metabolites are cell transforming and genotoxic to cultured mammalian cells.
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Cytotoxicity, chromosome aberrations and unscheduled DNA synthesis in cultured human diploid fibroblasts induced by sodium fluoride.
TL;DR: NaF causes DNA damage in human diploid fibroblasts in culture as determined by direct scintillation counting of [3H]thymidine incorporated into DNA during repair synthesis.
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17β-Estradiol-induced cell transformation and aneuploidy of Syrian hamster embryo cells in culture
Takeki Tsutsui,Takeki Tsutsui,Nubuko Suzuki,Shinya Fukuda,Masaki Sato,H Maizumi,John A. McLachlan,J. Carl Barrett +7 more
TL;DR: Findings are similar to the reported observations with the synthetic estrogen, diethylstilbestrol, and support the hypothesis that aneuploidy induction is important in cell transformation and possibly carcinogenesis induced by estrogens.
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Colcemid-induced neoplastic transformation and aneuploidy in Syrian hamster embryo cells
TL;DR: Treatment of Syrian hamster embryo cells in culture with 0.1 micrograms/ml colcemid resulted in morphological and neoplastic transformation of the cells, consistent with a role of carcinogen-induced chromosome non-disjunction in carcinogenesis.