Takuya Saiwaki

TL;DR: It is reported here that importin α accumulates reversibly in the nucleus in response to cellular stresses including UV irradiation, oxidative stress, and heat shock, and the findings suggest that the stress-induced nuclear accumulation of importinα can be involved in a common physiological response to various stress conditions.

TL;DR: It is found that importin α migrated into the nucleus without the addition of importin β, Ran or any other soluble factors in an in vitro transport assay, suggesting that the nuclear import machinery for importinα at individual nuclear pore complexes may be regulated by reaction(s) that require ATP hydrolysis.

TL;DR: It is reported here that importin α is able to carry CaMKIV into the nucleus without the need for importin β or any other soluble proteins in digitonin‐permeabilized cells.

TL;DR: The identification of a putative RNA-binding protein of 293 residues as another binding partner of the FHA domain of pKi-67 (referred to as NIFK for nucleolar proteininteracting with the F HA) is reported on, suggesting that hNIFK interacts with Ki-FHA in a mitosis-specific and phosphorylation-dependent manner.

TL;DR: It is reported here that a decrease in stress-induced ATP is associated with an increase in cytoplasmic Ran levels and a collapse of Ran distribution, and this indicates that the decrease in ATP levels induced by cellular stress causes a decreases in RanGTP levels andA collapse in Ran distribution.