Showing papers by "Tamara Beres Lederer Goldberg published in 2019"
TL;DR: Many women use combined hormonal contraceptives during adolescence during which they are accruing peak areal bone mineral density (BMD) that relates to lifetime fracture risk, and this work compared peak BMD accrual in adolescents using and not using CHC.
Abstract: Objective Many women use combined hormonal contraceptives (CHC) during adolescence during which they are accruing peak areal bone mineral density (BMD) that relates to lifetime fracture risk. To build BMD requires formation with which CHC-related exogenous oestrogen may interfere. We compared peak BMD accrual in adolescents using and not using CHC. Design/participants We performed literature searches for prospective published peer-reviewed articles providing 12- to 24-month BMD change in adolescent (12- to 19-year-old) women using CHC vs CHC-unexposed control women. Methods Meta-analyses used random-effects models to assess BMD change rate at lumbar spine (LS) and other sites in adolescent CHC users vs CHC nonusers. Results Literature searches yielded 84 publications of which nine were eligible. Adolescent-only data were sought from cohorts with wider age inclusions. The 12-month LS meta-analysis with eight paired comparisons in 1535 adolescents showed a weighted mean BMD difference of -0.02 (95% confidence interval [CI]: -0.05 to 0.00) g/cm2 in CHC-exposed adolescents (P = 0.04). The 24-month LS meta-analysis with five paired comparisons in 885 adolescents showed a highly significant weighted mean BMD difference of -0.02 (95% CI: -0.03 to -0.01) g/cm2 in CHC-exposed adolescents (P = 0.0006). Heterogeneities by I2 were 96% and 85%, respectively. Insufficient data for other bone sites precluded quantitative analysis. Conclusion Given that adolescent exposure to CHC appears to be increasing, this evidence for potential impairment of peak spinal BMD accrual is of concern and suggests a potential public health problem. Randomized controlled trial data are needed to determine CHC effects on adolescent bone health.
35 citations
TL;DR: Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls, and an increase in bone mineral density and bone mineral content for each additional year.
Abstract: Objective The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 μg EE/150 μg desogestrel), oral contraceptives 2 (n = 66) (30 μg EE/3 mg drospirenone), and a control group (n = 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional year. There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls.
19 citations
TL;DR: In this article, a systematic review of the current literature and systematic identification of common polymorphisms linked to genes correlated with joint mobility in elite rhythmic gymnastics was performed. But only one study was eligible for this systematic review.
Abstract: Rhythmic gymnastics has been an Olympic sport since 1984, however, there are relatively few studies about this sport. In order to understand whether genetic predisposition could play a role in defining the flexibility phenotype in rhythmic gymnastics, the purpose of this study was to review the current literature and systematically identify common polymorphisms linked to genes correlated with joint mobility in elite rhythmic gymnastics. Systematic computerized searches were performed from 1950 to 2017 in the following databases: Medline, Embase, Cinahl, Lilacs, SPORTDiscus, Web of Science, Scopus and the Cochrane Central. Although the search initially identified 9761 studies, after removing duplicates and excluding by title and abstract, only 10 studies demonstrated potential to be included. After reading of full-texts, 9 studies were entered in the qualitative synthesis, thus only 1 study was eligible for this systematic review. The results of Tringali's study demonstrated that the COL5A1 CT genotype was linked to high joint mobility and to the occurrence of genu recurvatum. From this systematic review, further investigations are suggested to confirm the results of involving genes related to physiological and anthropometric determinants of rhythmic gymnastics performance.
4 citations
01 Jan 2019
TL;DR: For instance, the authors in this paper propose a postgraduate program in Gynecology, Obstetrics, and Mastology at the Universidade do Norte do Paraná in Brazil.
Abstract: a Departamento de Educação Física, Universidade Estadual do Norte do Paraná, Grupo de Estudos em Adaptações Biológicas do Treinamento Infantil-GEABTI, Jacarezinho, PR, Brasil b Curso de Educação Física, Universidade Estadual do Norte do Paraná, Grupo de Estudos em Adaptações Biológicas do Treinamento Infantil-GEABTI, Jacarezinho, PR, Brasil c Diretoria de Operações Acadêmicas da Graduação Presencial, Ciências Biológicas e Saúde, Tutoria eletrônica, Universidade do Norte do Paraná, Londrina, PR, Brasil d Postgraduate Program in Gynecology, Obstetrics, and Mastology, Discipline of Adolescent Medicine, Department of Pediatrics, UNESP, Universidade Estadual Paulista, Faculdade de Medicina, Câmpus de Botucatu, Brasil e Departamento de Histologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, PR, Brasil f Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, PR, Brasil