T
Tanja Ball
Researcher at Medical University of Vienna
Publications - 28
Citations - 1561
Tanja Ball is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Immunoglobulin E & Allergen. The author has an hindex of 20, co-authored 28 publications receiving 1534 citations. Previous affiliations of Tanja Ball include Albert Einstein College of Medicine & Vienna General Hospital.
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Journal ArticleDOI
The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin.
TL;DR: Structural homology indicates that the basic features of the G actin-profilin interaction are conserved in all eukaryotic organisms, but suggests that mechanistic differences in the binding of proline-rich ligands may exist.
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Induction of antibody responses to new B cell epitopes indicates vaccination character of allergen immunotherapy.
Tanja Ball,Wolfgang R. Sperr,Peter Valent,Jonas Lidholm,Susanne Spitzauer,Christof Ebner,Dietrich Kraft,Rudolf Valenta +7 more
TL;DR: The finding that immunotherapy induced antibody responses against previously not recognized B cell epitopes indicates the vaccination character of this treatment and emphasizes the need for novel forms of component‐resolved immunotherapy.
Journal ArticleDOI
Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination
Margarete Focke,Vera Mahler,Tanja Ball,Wolfgang R. Sperr,Yasamin Majlesi,Peter Valent,Dietrich Kraft,Rudolf Valenta +7 more
TL;DR: It is demonstrated that synthetic hypoallergenic peptides derived from B cell epitopes of major allergens represent safe vaccine candidates for the treatment of IgE‐ mediated allergies.
Journal Article
Immunization with Purified Natural and Recombinant Allergens Induces Mouse IgG1 Antibodies That Recognize Similar Epitopes as Human IgE and Inhibit the Human IgE-Allergen Interaction and Allergen-Induced Basophil Degranulation
Susanne Vrtala,Tanja Ball,Susanne Spitzauer,Budhi Pandjaitan,Cenk Suphioglu,Bruce Knox,Wolfgang R. Sperr,Peter Valent,Dietrich Kraft,Rudolf Valenta +9 more
TL;DR: The data indicate that 1) the allergenic potency of a protein may be related to its overall immunogenicity and 2) prolonged immunization with single purified recombinant allergens induces protective IgG Abs.
Journal ArticleDOI
Genetically engineered and synthetic allergen derivatives: candidates for vaccination against type I allergy.
Rudolf Valenta,Susanne Vrtala,Margit Focke-Tejkl,Agnes Bugajska-Schretter,Tanja Ball,Anna Twardosz,Susanne Spitzauer,Hans Grönlund,D. Kraft +8 more
TL;DR: Molecular strategies which have been recently applied to generate genetically engineered and synthetic hypoallergenic allergen derivatives for patient-tailored and safe vaccination against Type I allergy are reviewed.